Vol. 2 No. 8 Nov 2016
Upcoming Events

Laser Microdissection Training/Information Session 
3pm Thursday, Nov 10, 2016
Toxicology Building, Rm 2104
Centennial Campus, NC State University

Save the Date!
First Annual CHHE Science Symposium
February 16, 2017  ALL DAY 

Location TBD
Laser Microdissection: November 10, 2016 3:00pm: Comparative Pathology Core (CPC) is sponsoring a Laser Microdissection (LMD) information session for CHHE members, their post docs, graduate students and staff.  CHHE members have access to the Leica Laser Microdisection System LMD 7000 and CPC pathology support for their LMD projects.   Learn about LMD from Leica representatives and bring LMD questions for Leica expert and CPC pathologist consultation; there will be ample time after the 45 min presentation for discussion.
LMD makes it possible to separate relevant and non-relevant cells in tissues at the microscopic level.  Researchers can isolate homogeneous, ultra-pure samples from heterogeneous organs and pathologies, down to single cells, and analyze these molecularly, such as with genomics, proteomics, etc.
The Comparative Pathology Core (CPC) has a new email address!
Please contact the CPC with any and all comparative pathology questons - Dr. Tokarz, Dr. Shive, and Dr. Linder

NIEHS Fest: December 6-8, 2016,  NIEHS turns 50 this year and they are celebrating with a meeting in Durham in December.  The meeting is for scientists, students, post-docs, and community members.  It will be great if CHHE is well represented there. Registration is free. 

First Annual CHHE Science Symposium: February 16, 2017
Mark your calendars to attend the first annual CHHE Science Symposium on February 16, 2017. This year the symposium will feature research by CHHE members in the area of toxic metals from exposures to model organisms and human populations. Dr. Linda Birnbaum, Director of the National Institute of Environmental Health Sciences and the National Toxicology Program will provide opening remarks to kick off an exciting day of presentations and posters. Dr. Michael Waalkes, (NCI/NIEHS), a pioneering research scientist who has made seminal contributions to the toxic metal field will be the keynote speaker.
Poster sessions will be open to all research areas and CHHE members as well as graduate students and post-docs. Be on the lookout for more specifics in the coming months and save the date!

Associate Membership Available for Post-doctoral fellows: Postdocs and Research Associates with interests in Environmental Health Science can apply for Associate Membership in the Center. Prospective new members may self-nominate or be nominated by a CHHE member. The criteria for Associate Membership in the Center are: 1) Postdoc or Research Associate status at one of the CHHE partners; 2) significant interest in environmental health science; and 3) relevance of the individual’s research program to environmental health science.

Welcome New Members
Full Membership
Sky Reece, Research Assistant Professor - Dept. of Physiology Research, ECU

Associate Membership
Brita Kilburg-Basnyat, Postdoctoral Scholar - Dept. of Pharmacology, ECU

Career Development
All investigators but particularly Early Stage Investigators are encouraged to work with the Career Development Core in development of their grants.  Talk to Chris McGahan to set up a chalk talk to help organize ideas for your next proposal.

Proteomics Section
Want to know more about what Proteomics can do for you?
Michael Bereman, proteomics section leader, tells you all in a new video.  Watch it here: Watch here.

Funding Resources
CHHE is increasing the amount of seed funding it provides its members from $3000 to $5,000.  Increased amount is retroactive to April 1, 2016.

Look at how others are using the seed funds:

Mike Cowley - to support his lab's use of the Comparative Pathology Core (CPC) using mice liver samples.

David Aylor - to collaborate with the CPC to gather histopathological phenotypes on DES-exposed mice.

Seth Kullman - to support his lab's use of the Genome Science Laboratory (GSL) to conduct RNAseq experiments with human marrow derived mesenchymal stem cells.

Krista McCoy (ECU) - to purchase SULF, mice and housing, kits, and RNA and proteins.  Dr. McCoy will also be using the CPC, GSL and the Proteomics Section.

For more information go to: Seed Funds  Be sure to cite the Center on all publications and presentations that use center resources.

COEC Update

Community Outreach and Engagement Core

This month, the COEC got its three community mini grantees up and running and we are so excited to see their projects start getting off the ground. Katy was in Omaha, Nebraska this month at the Engagement Scholarship Consortium's annual conference. She presented a poster on her work with Cathrine Hoyo and community members from Northeast Durham on reducing exposure to toxic metals, and the process of turning traditional research methods into community-engaged research. 

The Career Development Core hosted a "Grant Writing Workshop: From the Reviewer's Perspective" last month lead by Dr. Kenneth Adler.  This workshop examined framing applications that would maximize the chances of piquing reviewers' interest.  We had several early stage investigators in attendance and the workshop was productive.


PINS: Remember when submitting your grants, be sure to select "Center for Human Health and the Environment" as a center in PINS.

Acknowledgements: Remember to cite our CHHE grant P30ES025128 in publications if CHHE has provided you services, facility core use, seed/pilot project funds etc. NIH tracks this as an important CHHE metric.


CHHE Logo: Please use the CHHE logo in your presentations. You can find it on the website 

CHHE Resources and Facilities Page for NIH Grants is now available on the CHHE



Jamie DeWitt (ECU) is now an Associate Editor at the journal Toxicology and Applied Pharmacology. Congratulations. 

David Buchwalter provided expert commentary in a WRAL article on the widespread presence of hexavalent chromium in North Carolina ground water (  Previous detection of the carcinogen in well water was viewed as evidence of ground water contamination by coal ash. The recent study by Duke investigators revealed that hexavalent chromium is wide-spread in ground water in the Piedmont region and is likely derived from rock formations within this region.  David provided a toxicologist’s view of the presence of hexavalent chromium in drinking was and safety concerns for those exposed to the metal in their drinking water.

On September 13, Greg Kearney (ECU) presented "Reducing Asthma among Rural and Under-served Populations in Eastern NC" at the Forum on Sustainable In-Home Asthma Management - State of the State and Open Discussion at University of North Carolina - CH. This event was hosted by US HUD and CDC.
John Meitzen tells all about brains at the NC Museum of Science's Haunted Extravaganza

CHHE Member Resources 
CHHE offers a host of resources for Center members: seed money for use in Facility Cores, Facility Cores for Pathology, Proteomics, Genomics, and Metabolomics, bioinformatic support, career development opportunities, travel funds, and more.  Check out the website for more details.  And, remember, if you take advantage of these resources be sure to cite the Center (P30ES025128) in the acknowledgments of papers.

Research Money for CHHE members: CHHE Seed Funds
CHHE is providing up to $5000/year to each CHHE member to defray the cost associated with using the Comparative Pathology Core (immunohistochemical staining , tissue embedding and processing, etc.) or the Systems Technologies Core, including the Genomics (RNAseq etc), Proteomics (targeted and discovery proteomics), and Metabolomics sections (analysis of endorgenous and exogenous compounds; metals, xenobiotics etc) for environmental health science related projects. CHHE will also consider providing funds to support EHS research associated with the Integrative Health Sciences Facility and Community Outreach and Engagement Cores. For more details, click on 

CHHE 2016 Travel/Workshop Award Announcement - - Rolling deadline
One of CHHE's missions is to support career development of new and early stage investigators. As part of the effort, CHHE will provide awards (up to $1,000) to help defray the cost of travel to scientific meetings or small symposia relevant to environmental health science or a workshop that will provide new skills. Travel/Workshop awards will be reviewed and prioritized by members of the 
Career Development Core. Your request should be succinct (less than 250 words) and document the importance of attending the requested meeting/workshop. Please aldo include the entire budget for travel/registration, etc. Please send your proposals to Jackie Broughton.

**See the for more information**

Recent CHHE Publications
Evolution of phosphorus speciation with depth in an agricultural soil profile
By: Eriksson, Ann Kristin; Hillier, Stephen; Hesterberg, Dean; et al.
Geoderma Volume: 280 Pages: 29-37 Published: OCT 15 2016

Mucous membrane pemphigoid in dogs: a retrospective study of 16 new cases
By: Tham, Heng L.; Olivry, Thierry; Linder, Keith E.; et al.
Veterinary Dermatology Volume: 27 Issue: 5 Pages: 376-+ Published: OCT 2016

Impact of a western diet on the ovarian and serum metabolome
By: Dhungana, Suraj; Carlson, James E.; Pathmasiri, Wimal; Sumner, Susan; et al.
Maturitas Volume: 92 Pages: 134-142 Published: OCT 2016

The Importance of the Biological Impact of Exposure to the Concept of the Exposome
By: Dennis, Kristine K.; Auerbach, Scott S.; Balshaw, David M.; Sumner, Susan; et al.
Environmental Health Perspectives Volume: 124 Issue: 10 Pages: 1504-1510   Published: OCT 2016

Advancing Exposure Science through Chemical Data Curation and Integration in the Comparative Toxicogenomics Database
By: Grondin, Cynthia J.; Davis, Allan Peter; Wiegers, Thomas C.; King, Benjamin L.; Wiegers, Jolene A.; Reif, David M.; Hoppin, Jane A.; Mattingly, Carolyn J.; et al.
Environmental Health Perspectives Volume: 124 Issue: 10 Pages: 1592-1599   Published: OCT 2016

Fungal biomineralization of montmorillonite and goethite to short-range-ordered minerals
By: Li, Huan; Hu, Shuijin; Polizzotto, Matthew L.; et al.
Geochimica ET Cosmochimica Acta Volume: 191 Pages: 17-31 Published: OCT 2016

Life Inside an Acorn: How Microclimate and Microbes Influence Nest Organization in Temnothorax Ants
By: Karlik, Joseph; Epps, Mary Jane; Dunn, Robert R.; et al.
Ethology Volume: 122 Issue: 10 Pages: 790-797 Published: OCT 2016

Early Activation of Th2/Th22 Inflammatory and Pruritogenic Pathways in Acute Canine Atopic Dermatitis Skin Lesions
By: Olivry, Thierry; Mayhew, David; Paps, Judy S.; Linder, Keith E. et al.
Journal of Investigative Dermatology Volume: 136 Issue: 10 Pages: 1961-1969   Published: OCT 2016


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Center for Human Health and the Environment · NC State University · Campus Box 7633 · Raleigh, NC 27607 · USA

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