Vol. 1 No.7 January 2016
Upcoming Events

January 22, 2016 Special CHHE Seminar
NIEHS Branch Chiefs visit NCSU

The Center for Human Health and the Environment presents Cindy Lawler and Claudia Thompson: "Program Priorities and Grant Opportunities in the Genes, Environment, and Health Branch and the Population Branch of NIEHS"
9:30 am Toxicology Building Auditorium 

March 10, 2016 Pilot Project Proposals Due

Details located here
April 8, 2016 CHHE Retreat: Save the Date
12:00-6:30 JC Raulston Arboretum
More details to come

CHHE Member Resources 
The CHHE has cores for members to use to enhance their research. Seed money is available to members to spend in the cores.  These cores are:

The Comparative Pathology Core  provides pathology training, laser capture microdissection and pathology assessment of a diverse range of model organisms as well consultation
and opportunities for collaboration.

The Integrative Health Science Facility Core can help you translate your findings from animal/cell models to humans or vice versa.  This core can help you obtain human tissues/specimens, help with conduct of human studies (questionnaire development, IRB assistance), use of the comparative toxicogenomic database (CTD, either with specialized training or data curation, access to clinical populations at ECU, and much more.

The Systems Technologies Core provides genomic, metabolomics and proteomic analysis as well as consultation and opportunities for collaboration.

Dedicated Bioinformatic support is available for CHHE members.

Career Development Core provides grant writing help to early stage investigators and those new to environmental health sciences research. This core also provides funding for early stage investigators to attend a scientific meeting/workshop. 

Community Outreach and Engagement Core (COEC) extends the reach of our research to communities in NC and beyond. The COEC can help you translate your research findings for the general public.
**See the for more information**

COEC Update

Community Outreach and Engagement Core

The COEC held the first of multiple focus groups with traditional and subsistence fishermen as part of its ongoing Fish Consumption Advisory Project. On December 1, the COEC met with members of the Jordan Lake Striper Club to discuss how to improve the communication of North Carolina’s fish consumption advisories.  Focus groups with other affected communities will continue in January and February.

The COEC contributed to the December submission of a proposal to the National Institute on Minority Health and Health Disparities (NIMHD) for the funding of a Transdisciplinary Collaborative Center for Health Disparities Research on Chronic Disease Prevention, an effort led by Cathrine Hoyo and involving researchers from NC State, Duke, UNC, and NCCU. With the funding, the COEC will help implement and disseminate information related to intervention strategies to reduce toxic metal exposures in Durham communities in collaboration with community partners.

The COEC, several CHHE scientists and other researchers from NC State, and representatives from the NC Department of Health and Human Services and NC Department of Agriculture and Consumer Services wrapped up 2015 discussing outreach efforts regarding the potential health effects associated with glyphosate. 


PINS: Remember when submitting your grants, be sure to select CHHE as a center in PINS.

Research Teams are meeting to discuss topics to work on together and what types of events/enrichment activities they would like CHHE to offer.

Acknowledgements: Please remember to cite our CHHE grant P30ES025128 in publications if CHHE has provided you services, facility core use, seed/pilot project funds etc. NIH tracks this as an important CHHE metric.

CHHE Logo: Please use the CHHE logo in your presentations. You can find it on the

CHHE Resources and Facilities Page for NIH Grants is now available on the CHHE


Upcoming CHHE Seminars:
Toxicology Building Auditorium:

Claudia Thompson and Cindy Lawler, NIEHS Branch Chiefs - "Program Priorities and Grant Opportunities in the Genes, Environment, and Health Branch and the Population Health Branch of the NIEHS". Jan. 22, 2016 - 9:30 am

Laura Beane Freeman, National Cancer Institute - "Pesticides and Cancer: New Findings on an Old Question".  
Feb. 8, 2016 - 4:00 pm

Dana Dolinoy - University of Michigan - "Perinatal Environmental Exposures: Effects on Metabolic Homeostasis and the Epigenome". April 19, 2016  4:00 pm
Seminars: Send Jackie seminar announcements/events etc. for the CHHE calendar.


Galen Collier, from NCSU received a CHHE Travel Award to attend the Society of Toxicology meeting in March 2016. 

David Collier, from the Brody School of Medicine, East Carolina University, Greenville, North Carolina, presented a talk entitled “Benzoic Acid as an Obesogenic Xenobiotic: Metabolomic Analysis of Weight Loss Non-Responders” in the plenary session of the 2015 Association of Academic Health Centers Research Meeting in Washington DC on 12/3/2015. This work is the result of collaboration between Collier’s group and Dr. Susan Sumner’s group at RTI.  This presentation included the CHHE logo!

CHHE members at ECU, led by Dr. Greg Kearney (Kearney, David Collier and Kymberly Gowdy) and including Dr. Seung Cho at RTI, were awarded a pilot grant from the Brody Brothers Endowment for a project entitled “Environmental asthma among rural high risk and underserved children in eastern NC”. This project will evaluate the effects of environmental exposures on asthma severity among high risk children living in rural environments.

Kymberly Gowdy, from the Brody School of Medicine, East Carolina University, Greenville, North Carolina, has been selected as the recipient of a $450,000 HEI’s 2015 Walter A. Rosenblith New Investigator Award for her proposal “Scavenger Receptor B1 Regulates Oxidized Lipid Driven Pulmonary and Vascular Inflammation After Ozone Exposure." 

CHHE members at ECU (David Collier and Dr. Sid Mitra) hosted a round table discussion with water quality researchers at ECU, the Executive Director of Sound Rivers Inc. (reperesenting the Pamlico-Tar and Neuse River watersheds) and the Pamlico Tar River’s River Keeper to explore environmental contaminant issues of relevance to the health and well-being of the population of eastern NC.  We expect ongoing dialogue to help inform our research directions in the future.

Jan 22 9:30 am Toxicology Auditorium: Special Seminar about NIEHS Research Programs  
We're lucky to have the opportunity to host two NIEHS extramural branch chiefs to talk about two major research areas at NIEHS:  1) Genes, Environment, and Health AND 2) Population Health.  Cindy Lawler, the Branch Chief of the Genes, Environment, and Health Branch will talk about her branch's research funding strategy and Claudia Thompson, the Branch Chief of the Population Health Branch and the CHHE's program officer, will talk about her program's funding opportunities.  They will speak for about 30 minutes each with time for questions afterward.  Please join us for this interesting and informative seminar.

2016 Pilot Project Call 
CHHE released its next call for Pilot Projects.  All CHHE members as well as NC State, East Carolina University, and NCCU faculty are eligible for these one year up to $25,000 research grants.  Due March 10, 2016.  Please visit the website for more details and to obtain 2016 CHHE Pilot Project instructions.
Remember you can consult with the CHHE bioinformatician Dereje Jima for help with study design and you can also use your CHHE seed money to help get the proposal started

CHHE State of the Center and Social
To kick off our first 8 months of the center, we had a social on December 10.  Rob Smart, Director, gave an overview of the successes of the center since we started in April and gave updates on some new initiatives (watch your email).  Alan Rebar, Vice Chancellor of Research, Innovation, and Economic Development, was there to join in the festivities.  We hope to have more social events where we can talk science in an informal setting.

Research Money for CHHE members: CHHE Seed Funds
CHHE is providing up to $3000/year to each CHHE member to defray the cost associated with using the Comparative Pathology Core (immunohistochemical staining , tissue embedding and processing, etc.) or the Systems Technologies Core, including the Genomics (RNAseq etc), Proteomics (targeted and discovery proteomics), and Metabolomics sections (analysis of endorgenous and exogenous compounds; metals, xenobiotics etc) for environmental health science related projects. CHHE will also consider providing funds to support EHS research associated with the Integrative Health Sciences Facility and Community Outreach and Engagement Cores. For more details, click on link.

CHHE 2016 Travel/Workshop Award Announcement - - Rolling deadline
One of CHHE's missions is to support career development of new and early stage investigators. As part of the effort, CHHE will provide awards (up to $1,000) to help defray the cost of travel to scientific meetings or small symposia relevant to environmental health science or a workshop that will provide new skills. Travel/Workshop awards will be reviewed and prioritized by members of the
Career Development Core. Your request should be succinct (less than 250 words) and document the importance of attending the requested meeting/workshop. Please aldo include the entire budget for travel/registration, etc. Please send your proposals to Jackie Broughton.

Event of Interest: NIH Transgenerational Workshop - April 21-22, 2016

CHHE Publications
Comparative sodium transport patterns provide clues for understanding salinity and metal responses in aquatic insects.
Scheibener SA, Richardi VS, Buchwalter DB.
Aquat Toxicol. 2015 Dec 17;171:20-29. doi: 10.1016/j.aquatox.2015.12.006. [Epub ahead of print]

Attraction and oviposition preferences of Phlebotomus papatasi (Diptera: Psychodidae), vector of Old-World cutaneous leishmaniasis, to larval rearing media.
Marayati BF, Schal C, Ponnusamy L, Apperson CS, Rowland TE, Wasserberg G.
Parasit Vectors. 2015 Dec 30;8(1):663. doi: 10.1186/s13071-015-1261-z.

Epistatic Partners of Neurogenic Genes Modulate Drosophila Olfactory Behavior.
He X, Zhou S, St Armour GE, Mackay TFAnholt RR.
Genes Brain Behav. 2015 Dec 17. doi: 10.1111/gbb.12279. [Epub ahead of print]

Genetic sex and the volumes of the caudate-putamen, nucleus accumbens core and shell: original data and a review.
Wong JE, Cao J, Dorris DM, Meitzen J.
Brain Struct Funct. 2015 Dec 14. [Epub ahead of print]

The genetic basis of natural variation in mushroom body size in Drosophila melanogaster.
Zwarts L, Vanden Broeck L, Cappuyns E, Ayroles JF, Magwire MM, Vulsteke V, Clements J, Mackay TF, Callaerts P.
Nat Commun. 2015 Dec 11;6:10115. doi: 10.1038/ncomms10115.

Gut bacteria mediate aggregation in the German cockroach.
Wada-Katsumata A, Zurek L, Nalyanya G, Roelofs WL, Zhang A, Schal C.
Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15678-83. doi: 10.1073/pnas.1504031112. Epub 2015 Dec 7.

Canine epidermolysis bullosa acquisita: a retrospective study of 20 cases.
Bizikova P, Linder KE, Wofford JA, Mamo LB, Dunston SM, Olivry T.
Vet Dermatol. 2015 Dec;26(6):441-e103. doi: 10.1111/vde.12255. Epub 2015 Sep 15.

Impact of Low-Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study.
Rebuli ME, Camacho L, Adonay ME, Reif DMAylor DLPatisaul HB.
Toxicol Sci. 2015 Dec;148(2):341-54. doi: 10.1093/toxsci/kfv163. Epub 2015 Jul 23.

Efficacy of Trypsin in Treating Coral Snake Envenomation in the Porcine Model.
Parker-Cote JL, O'Rourke DP, Brewer KL, Lertpiriyapong K, Punja M, Bush SP, Miller SN, Meggs WJ.
J Med Toxicol. 2015 Dec;11(4):430-2. doi: 10.1007/s13181-015-0468-x.

Chronic Treatment with Naltrexone Prevents Memory Retention Deficits in Rats Poisoned with the Sarin Analog Diisopropylfluorophosphate (DFP) and Treated with Atropine and Pralidoxime.
Brewer KL, Tran T, Meggs WJ.
J Med Toxicol. 2015 Dec;11(4):433-8. doi: 10.1007/s13181-015-0480-1.

Longevity GWAS Using the Drosophila Genetic Reference Panel.
Ivanov DK, Escott-Price V, Ziehm M, Magwire MM, Mackay TF, Partridge L, Thornton JM.
J Gerontol A Biol Sci Med Sci. 2015 Dec;70(12):1470-8. doi: 10.1093/gerona/glv047. Epub 2015 Apr 28.

Reagent for Evaluating Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Performance in Bottom-Up Proteomic Experiments
By: Beri, Joshua; Rosenblatt, Michael M.; Strauss, Ethan; Bereman, Michael; et al.
ANALYTICAL CHEMISTRY  Volume: 87 Issue: 23 Pages: 11635-11640 Published: DEC 1 2015

Consistent testing for recurrent genomic aberrations
By: Walter, V.; Wright, F. A.; Nobel, A. B.
BIOMETRIKA  Volume: 102 Issue: 4 Pages: 783-796 Published: DEC 2015

Genome-wide assessment of recurrent genomic imbalances in canine leukemia identifies evolutionarily conserved regions for subtype differentiation
By: Roode, Sarah C.; Rotroff, Daniel; Avery, Anne C.; Motsinger-Reif, A.; Breen, M.; et al.
CHROMOSOME RESEARCH Volume: 23 Issue: 4 Pages: 681-708 Published: DEC 2015
In vitro screening for population variability in toxicity of pesticide-containing mixtures
By: Abdo, Nour; Wetmore, Barbara A.; Chappell, Grace A.; Wright, Fred A.; et al.
ENVIRONMENT INTERNATIONAL Volume: 85 Pages: 147-155 Published: DEC 2015

Distribution and biomarker of carbon-14 labeled fullerene C-60 ([C-14(U)]C-60) in pregnant and lactating rats and their offspring after maternal intravenous exposure
By: Snyder, Rodney W.; Fennell, Timothy R.; Wingard, Christopher J.; Sumner, Susan C. J.; et al. JOURNAL OF APPLIED TOXICOLOGY Volume: 35 Issue: 12 Pages: 1438-1451 Published: DEC 2015

Distribution and biomarkers of carbon-14-labeled fullerene C-60 ([C-14(U)]C-60) in female rats and mice for up to 30 days after intravenous exposure
By: Sumner, Susan C. J.; Snyder, Rodney W.; Wingard, Christopher; et al.
JOURNAL OF APPLIED TOXICOLOGY Volume: 35 Issue: 12 Pages: 1452-1464 Published: DEC 2015

Cancer incidence and metolachlor use in the Agricultural Health Study: An update
By: Silver, Sharon R.; Bertke, Steven J.; Hines, Cynthia J.; Hoppin, Jane A.; et al.
INTERNATIONAL JOURNAL OF CANCER Volume: 137 Issue: 11 Pages: 2630-2643 Published: DEC 1 2015