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Vol. 2 No.1 May 2016
Upcoming Events

May 3rd CHHE Pathology Information Session
3 pm to 4 pm
Toxicology Auditorium
 
May 11, 2016 IPA Introduction & Hands-On Training
10 am to 12:00 pm
Toxicology Auditorium

May 19, 2016 Margaret Karagas, Dartmouth College
"Emerging evidence on the sources and health risks of arsenic exposure from the New Hampshire Birth Cohort Study"
4 pm to 5 pm
Toxicology Auditorium

Announcements
 
May 3, 2016 CHHE Pathology Information Session
Representatives from the CHHE Comparative Pathology Core and the UNC Animal Histopathology Core will be in the NCSU toxicology auditorium to talk about their services and many other UNC core facilities that can help your animal model studies. Histopathology, sample handling, laser capture micro dissection, virtual microscopy, morphometrics, tissue micro-arrays, human and animal tissue archives, publication support, electron microscopy, IHC protocol development and multiplex IHC and IF, are some of the services you can access at NCSU and/or UNC that relate to pathology studies. Everyone is welcome including faculty, graduate students, post-docs and lab managers.  Dr. Stephanie Montgomery will be there from UNC and you can also come meet our new CHHE comparative pathologist, Dr. Deborah Tokarz.  You can bring pathology related questions about your research!  3 pm - 4 pm, Toxicology Auditorium.


May 11, 2016 IPA Introduction & Hand-On Training
Ingenuity Pathway Analysis (IPA) is an all-in-one software application that enables you to analyze, integrate and understand complex data such as those derived from proteomics, metabolomics and RNAseq experiments.  IPA allows you to build interactive models of your experimental system.This hands-on training session will mainly focus on biological interpretation of expression data. Using IPA you will learn how to rapidly understand:pathway involvement and change, effected biological processes, causal regulators and their directional effect on genes, functions and diseases across multiple time points or doses. You will also learn to explore IPA's knowledge &discovery tools that allow you to relate the mostrecent literature findings to your research. Bring your laptops. There will be afternoon sessions on more advanced topics. 10 am - 12 pm, Toxicology Auditorium

June 19-24, 2016 Gordon Conference on Environmental Endocrine Disruptors
Heather Patisaul is organizing a Gordon Conference on Environmental Endocrine Disruptors:  “The Next Generation of Endocrine Disruption: Emerging Contaminants, Tools and Research Approaches for Assessing Multigenerational Effects”.  It’s co-sponsored by NC State, NIEHS, and EPA. David Aylor is one of the invited speakers.  The link to register is here: To Register please visit
https://www.grc.org/programs.aspx?id=12743 

CHHE Proteomics Capabilities

Proteins are the vehicles of change in living organisms and proteomics is the large-scale determination of gene and cellular function at the protein level.  Unlike conventional methods for protein detection, liquid chromatography mass spectrometry (LC MS) can identify several 1000’s of proteins in cellular lysates/tissues and can also achieve absolute molecular specificity.  As a result LC MS has become the premiere analytical tool for proteomic studies. 
 
The CHHE Proteomics Section within the
Systems Technology Core is well equipped with the expertise and technology to tackle complex biological questions in relation to:
  • discovery proteomics,
  • protein interactions,
  • protein identification from gel slices, and
  • post translational modifications of proteins.
 The Section has two state-of-the-art mass spectrometers as well as one used for technology development.  Dr. Michael Bereman and newly hired Dr. Tara Nash (Research Scholar) are available for consultation on project feasibility, sample preparation, and storage as well as discussion/suggestions of other analytical technologies that may be beneficial for specific projects. Come visit us in the basement of the Toxicology Building 0212.
 

New Members
 
Aaron Hipp, Associate Professor of Community Health and Sustainability
Debra Tokarz, Comparative Veterinary Pathologist, Dept. of Molecular Biomedical Sciences

Kudos
 
Congratulations to David Aylor and Rob Smart for their recently NIEHS funded grants.  David Aylor’s U01 is Systems Toxicogenetics of Endocrine Disrupting Chemicals in Brain and includes Heather Patisaul as a co-Investigator.  Rob Smart’s R01 is on the Role of Long Intergenic Noncoding RNA in UVB-induced Apoptosis and Skin Cancer and includes CHHE members Michael Bereman, Jonathan Hall, Keith Linder, and Fred Wright as co-investigators.
 
Kym Gowdy landed a major equipment grant for a state of the art cell-sorter - a $509,000 NIH S10 grant for a BD Aria Fusion with 4 lasers (can do 10-12 color detection).  Description is below.  It should be of use to CHHE members as well since it has the BSLrequirements to sort human and infected cells which neither ECU or NCSU had capabilities to do beforehand.
https://www.bdbiosciences.com/us/instruments/research/cell-sorters/bd-facsaria-fusion/m/1526412/overview
 
Greg Kearney, ECU, co-wrote an editorial on climate change for the News and Observer Protecting health of North Carolinians means addressing climate change, April 21, http://www.newsobserver.com/opinion/op-ed/article73150047.html#storylink=cpy
 
John Meitzen gave a seminar on "Sex differences in striatal neurons" to the Neuroscience and Behavior graduate program at U. Massachusetts Amherst.
 
Jaime Willett, a graduate student in John Meitzen’s lab first-authored a new paper, 
“No Evidence for Sex Differences in the Electrophysiological Properties and Excitatory Synaptic Input onto Nucleus Accumbens Shell Medium Spiny Neurons. Willett JA, Will T, Hauser CA, Dorris DM, Cao J, Meitzen J. eNeuro. 2016 Feb 27;3(1).”
 
Stephanie Proano, another graduate student in John Meitzen’s lab has been accepted into SPINES, the Summer Program in Neuroscience, Ethics and Survival at the MBL in Woods Hole.  This is a prestigious, competitive admission program.  It's an intensive one-month experience that exposes trainees to neuroscience research, ethics and professional development opportunities including grant writing, teaching, public speaking, and work/family balance, and science related careers. 
 
David Reif was appointed as an Associate Editor at Environmental Health Perspectives. http://ehp.niehs.nih.gov/editorial-board/
 
CHHE member David Reif along with Nadia Singh and Dahlia Nielsen presented a one-day short course on Bioinformatics at Fayetteville State University as part of their NIH-funded Research Initiative for Scientific Enhancement (RISE) program to increase the number of well-prepared FSU biology, chemistry and psychology minority students entering biomedical and behavioral research. 
 
David Reif presented at an invited workshop from the European Chemicals Agency (ECHA) in Helsinki, Finland on "New Approach Methodologies in Regulatory Science".

David Reif was a panelist at the NIEHS Biomedical Career Symposium. http://tools.niehs.nih.gov/careerfair/
 
Jennifer Runkle and her group at the Cooperative Center for Climate and Satellites just finished their report “The Impacts of Climate Change on Human Health in the United States.
http://us11.campaign-archive2.com/?u=574d74f0666ca2db5284e3c20&id=8e2de82f95&e=925083025b
 
Rob Smart participated as an ad hoc member of the NIEHS Board of Scientific Councilors review of NIEHS intramural research programs.

Congratulations to the New CHHE Event Committee.  Our 2016 Event Committee members are David Aylor, Mike Cowley, John House, Katy May, Matt Polizzotto, and Jung-Ying Tzeng.  They'll be working together to organize a CHHE event in the coming year.  Please give them your suggestions for topics or structure.  Thanks for your help!
 
***Send your Kudos to Jane Hoppin every month***

2016 CHHE Retreat
The 2016 retreat for CHHE members was a success.  Over 50 members attended as well as five members of our Community Advisory Board and Jon Horowitz from the Office for Research, Innovation, and Economic Development.  It was a beautiful day and a great opportunity to meet each other, as well as learn more about the grant support of CHHE members, the results of the pilot projects, and the activities of the Community Outreach and Engagement Core (don’t forget to tweet about us!).  Our brainstorming activities always yield the same thing: more chances to get together and talk about science.  Look for some new things in the Fall.  In the mean time, be sure to share your suggestions and ideas about the center with your team leader and the event committee!  Thanks for attending!  You made it a success!

COEC Update

Community Outreach and Engagement Core

In April the COEC finally wrapped up their hard work on establishing the Center's social media pages, and the COEC's website pages. All of them are now up and running. Check them out! 
https://www.facebook.com/NCStateCHHE 
https://twitter.com/NCState_CHHE
https://chhe.research.ncsu.edu/coec
 
The COEC, along with AnnMarie Walton from UNC-CH, used focus group and survey results to create toolkits with fluorescent tracer activities for farmworker health outreach workers to use across NC that will educate and promote better handwashing practices in the field.
 
Katy May attended a SeaGrant conference to help graduate students become better communicators of their research. She came back with a lot of good ideas that can help even the most seasoned PhDs, so stay tuned!
 
We are always looking for more CHHE members to feature on our blog and social media sites. It's a great way to get people interested in your work, and practice your science communication skills! Take a look at some of our current blog posts, and if you'd like to be featured, email Katy
(kmay2@ncsu.edu). 
 

Funding Opportunities 
 
Acknowledgements: Remember to cite our CHHE grant P30ES025128 in publications if CHHE has provided services, facility core use, seed/pilot project funds etc. NIH tracks this as an important CHHE metric. "Research reported in this publication was supported NIEHS under award number P30ES025128 Center for Human Health and the Environment.".

University Global Partners Network www.ugpn.org has a call for proposals for collaboration with NC State sister institutions (University of Sao Paulo, Brazil; University of Surrey, UK; and University of Woolongong, Australia).  Researchers in Australia are particularly interested in collaborating with CHHE members.  Proposals are due May 3, 2016.  See details here: http://www.ugpn.org/Research/
 
NC State Office of Research, Innovation, and Economic Development has announced a new program GRIP (Game-Changing Research Incentive Program).  Pre-proposals due May 31, 2016
GRIP will allocate more than $1,500,000 over three years to fund exceptional research teams and projects that span NC State colleges. GRIP is intended to incentivize and support visionary research ideas that will result in large-scale extramural funding, award-winning research impacts, and first-class interdisciplinary graduate education and training. For more information about GRIP (including a copy of the RFP and a short video about the program) please visit https://research.ncsu.edu/rdo/funding/internal-funding/grip/.
 
Integrating Human Health and Well-Being with Ecosystem Services 
URL: 
http://www.epa.gov/research-grants/integrating-human-health-and-well-being-ecosystem-services 

Open Date: 02/22/2016 - Close Date: 04/21/2016 
The U.S. Environmental Protection Agency (EPA) announces the release of the Integrating Human Health and Well-Being with Ecosystem Services Request for Applications.  This RFA goal is to fund community-based research that will foster better understanding of how human health and well-being are interconnected with—and depend on—ecosystem services. Specifically, this research examines how communities can integrate ecosystem services with human health and well-being to inform their decision making and management practices. This RFA aims to develop information that allows communities to integrate environmental, societal and economic information and to better manage multiple stressors and their cumulative impacts on humans and ecosystems. The ultimate goal is to help communities achieve their own objectives while taking advantage of more relevant and accessible information about ecosystem services. The Integrating Human Health and Well-Being with Ecosystems Services RFA is part pf EPA’s Sustainable and Healthy Communities (SHC) Research program. The SHC Research Program provides useful science and tools for decision makers at all levels to help communities advance sustainability as well as achieve regulatory compliance.  SHC is collaborating with partners to conduct research that will result in science-based knowledge to guide decisions that will better sustain a healthy society and environment in America's communities. Partnerships and community engagement are strongly encouraged for this research.

Reminders

PINS: Remember when submitting your grants, be sure to select "Center for Human Health and the Environment" as a center in PINS.

Acknowledgements: Remember to cite our CHHE grant P30ES025128 in publications if CHHE has provided you services, facility core use, seed/pilot project funds etc. NIH tracks this as an important CHHE metric.

CHHE Logo: Please use the CHHE logo in your presentations. You can find it on the
website 

CHHE Resources and Facilities Page for NIH Grants is now available on the CHHE
website.

Seminars

Upcoming CHHE Seminars:

Margaret Karagas, Dartmouth College
"Emerging evidence on the sources and health risks of arsenic exposure from the New Hampshire Birth Cohort Study". May 19, 2016 Toxicology Auditorium 4:00 pm - 5:00 pm


Seminars: Send Jackie seminar announcements/events etc. for the CHHE calendar.

CHHE Member Resources 
 
The CHHE has cores for members to use to enhance their research. Seed money is available to members to spend in the cores.  These cores are:

The Comparative Pathology Core  provides pathology training, laser capture microdissection and pathology assessment of a diverse range of model organisms as well consultation
and opportunities for collaboration.


The Integrative Health Science Facility Core can help you translate your findings from animal/cell models to humans or vice versa.  This core can help you obtain human tissues/specimens, help with conduct of human studies (questionnaire development, IRB assistance), use of the comparative toxicogenomic database (CTD, ctdbase.org) either with specialized training or data curation, access to clinical populations at ECU, and much more.

The Systems Technologies Core provides genomic, metabolomics and proteomic analysis as well as consultation and opportunities for collaboration.

Dedicated Bioinformatic support is available for CHHE members.

Career Development Core provides grant writing help to early stage investigators and those new to environmental health sciences research. This core also provides funding for early stage investigators to attend a scientific meeting/workshop. 

 
Community Outreach and Engagement Core (COEC) extends the reach of our research to communities in NC and beyond. The COEC can help you translate your research findings for the general public.

Research Money for CHHE members: CHHE Seed Funds
CHE is providing up to $3000/year to each CHHE member to defray the cost associated with using the Comparative Pathology Core (immunohistochemical staining , tissue embedding and processing, etc.) or the Systems Technologies Core, including the Genomics (RNAseq etc), Proteomics (targeted and discovery proteomics), and Metabolomics sections (analysis of endorgenous and exogenous compounds; metals, xenobiotics etc) for environmental health science related projects. CHHE will also consider providing funds to support EHS research associated with the Integrative Health Sciences Facility and Community Outreach and Engagement Cores. For more details, click on 
link.

CHHE 2016 Travel/Workshop Award Announcement - - Rolling deadline
One of CHHE's missions is to support career development of new and early stage investigators. As part of the effort, CHHE will provide awards (up to $1,000) to help defray the cost of travel to scientific meetings or small symposia relevant to environmental health science or a workshop that will provide new skills. Travel/Workshop awards will be reviewed and prioritized by members of the 
Career Development Core. Your request should be succinct (less than 250 words) and document the importance of attending the requested meeting/workshop. Please aldo include the entire budget for travel/registration, etc. Please send your proposals to Jackie Broughton.


 
**See the http://chhe.research.ncsu.edu/ for more information**

CHHE Publications
 
The effect of surgery on sexual function in women with suspected gynecologic malignancies
Bretschneider, C. E.; Bensen, J. T.; Geller, E. J.; et al.
Conference: 42nd Annual Scientific Meeting of the Society-of-Gynecologic-Surgeons Location: Palm Springs, CA Date:APR 10-13, 2016 
Sponsor(s): Soc Gynecol Surg
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY Volume: 214 Issue: 4 Supplement: S Pages: S474-S474 Meeting Abstract: 15 Published: APR 2016
 

The Genetic Architecture of Natural Variation in Recombination Rate in Drosophila melanogaster.
Hunter, Chad M; Huang, Wen; Mackay, Trudy F C; et al.
PLoS genetics Volume: 12 Issue: 4 Pages: e1005951 Published: 2016-Apr
 

Urban Vegetative Cover Fragmentation in the US Associations with Physical Activity and BMI
Tsai, Wei-Lun; Floyd, Myron F.; Leung, Yu-Fai; McHale, Melissa R.; Reich, Brian J.; et al.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE Volume: 50 Issue: 4 Pages: 509-517 Published: APR 2016
 

Assessment of trace element impacts on agricultural use of water from the Dan River following the Eden coal ash release
Hesterberg, Dean; Polizzotto, Matthew L.; Crozier, Carl; et al.
INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT Volume: 12 Issue: 2 Pages: 353-363 Published: APR 2016
 

The effect of human population size on the breeding bird diversity of urban regions
Gagne, Sara A.; Sherman, Peter J.; Singh, Kunwar K.;  Meentemeyer, Ross K.;et al.
BIODIVERSITY AND CONSERVATION Volume: 25 Issue: 4 Pages: 653-671 Published: APR 2016
  

Inheritance of steroid-independent male sexual behavior in male offspring of B6D2F1 mice
McInnis, Christine M.; Bonthuis, Paul J.; Rissman, Emilie F.; et al.
HORMONES AND BEHAVIOR Volume: 80 Pages: 132-138 Published: APR 2016
 

The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons
Braasch, Ingo; Gehrke, Andrew R.; Smith, Jeramiah J.; Yoder, Jeffrey A; et al.
NATURE GENETICS Volume: 48 Issue: 4 Pages: 427-+ Published: APR 2016
 

The identification of additional zebrafish DICP genes reveals haplotype variation and linkage to MHC class I genes
Rodriguez-Nunez, Ivan; Wcisel, Dustin J.; Litman, Ronda T.; Yoder, Jeffrey A; et al.
IMMUNOGENETICS Volume: 68 Issue: 4 Pages: 295-312 Published: APR 2016
 

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis.
Joubert, Bonnie R; Felix, Janine F; Yousefi, Paul; Hoyo, Cathrine; et al.
American journal of human genetics Volume: 98 Issue: 4 Pages: 680-96 Published: 2016-Apr-7 (Epub 2016 Mar 31)
 

Structural perturbation of a dipalmitoylphosphatidylcholine (DPPC) bilayer by warfarin and its bolaamphiphilic analogue: A molecular dynamics study
 Ayee, Manuela Aseye Ayele; Roth, Charles William; Akpa, Belinda Sena
JOURNAL OF COLLOID AND INTERFACE SCIENCE Volume: 468 Pages: 227-237 Published: APR 15 2016
 

Adaptation and Evaluation of the Neighborhood Environment Walkability Scale in India (NEWS-India).
Adlakha D, Hipp JA, Brownson RC.
Int J Environ Res Public Health. 2016 Apr 2;13(4). pii: E401. doi: 10.3390/ijerph13040401.
 

TAK1 regulates Paneth cell integrity partly through blocking necroptosis.
Simmons AN, Kajino-Sakamoto R, Ninomiya-Tsuji J.
Cell Death Dis. 2016 Apr 14;7:e2196. doi: 10.1038/cddis.2016.98.
 

Impact of Environmental Chemicals on the Transcriptome of Primary Human Hepatocytes: Potential for Health Effects.
Mitchell RD 3rd, Dhammi A, Wallace A, Hodgson E, Roe RM.
J Biochem Mol Toxicol. 2016 Apr 19. doi: 10.1002/jbt.21801. [Epub ahead of print]
 

Laboratory and Field Evaluation of Zyrox Fly Granular Bait against Asian and German Cockroaches (Dictyoptera: Blattellidae).
Matos YK, Schal C.
J Econ Entomol. 2016 Apr 27. pii: tow092. [Epub ahead of print]
 

Aggregate Entropy Scoring for Quantifying Activity across Endpoints with Irregular Correlation Structure.
Zhang G, Marvel S, Truong L, Tanguay RL, Reif DM.
Reprod Toxicol. 2016 Apr 27. pii: S0890-6238(16)30062-4. doi: 10.1016/j.reprotox.2016.04.012. [Epub ahead of print]






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