Vol. 2 No. 10 Jan 2017          Happy New Year from CHHE
Coming Soon

CHHE member survey, please respond promptly.

Upcoming Events

1/12 - Burroughs Wellcome Lecture
Dr. Robin D. Knight, University of California San Diego
"Mapping Microbes on Scales from our Bodies to our Planet: From the Human Microbiome Project to the Earth Microbiome Project"
David Clark Labs Rm 101, 3:30 pm - 4:30 pm.

1/24 - CHHE/Toxicology Co-sponsored Seminar
Darryl Zeldin, NIEHS
"Thromboxane (TXA2) Attenuates Th9 Cell Differentiation and Function During Allergic Lung Inflammation"
Toxicology Building Auditorium 4:00 pm - 5:00 pm

2/16 - First Annual CHHE Science Symposium
"Toxic Metals - From Exposures and Model Organisms to Human Populations"
9:00 am - 5:00 pm
James B. Hunt Library, Duke Energy Hall AB
North Carolina State University

3/23 - East Carolina University's Climate Change and Health Conference
"Climate Change and Health: Focus on Eastern N.C."
9:00 am - 3:00 pm
East Carolina Heart Institute
East Carolina University
2016 CHHE Fall Pilot Project Awards
Congratulations to the recipients of the 2016 CHHE Fall Pilot Project Awards!  CHHE awarded six Pilot Projects to investigators at NCSU and ECU's Brody School of Medicine. These year long projects are intended to foster collaboration among CHHE members and generate preliminary data for larger grant applications to NIEHS.

Investigating the Interplay between Genetic and Environmental Mechanisms Underlying Amyotrophic Lateral Sclerosis Etiology
Michael S. Bereman, (PI), NCSU
Carolyn Mattingly, (Co-I), NCSU
Debra Tokarz, (Co-I), NCSU
Antonio Planchart, (Co-I), NCSU

The Role of C/EBPβ in Regulating p53 Pro-Apoptotic Transcriptional Activity in Response to UVB Solar Radiation
Jonathan R. Hall, (PI), NCSU
John S. House, (Co-I), NCSU
Yoshiaki Tsuji, (Co-I), NCSU
Robert C. Smart, (Co-I), NCSU

Reducing Pollutant-Induced Hypospadias: is Nrf2 Driving the Rescue?
Krista A. McCoy, (PI), ECU
Michael S. Bereman, (Co-I), NCSU

A Bioinformatics and Molecular Modeling Approach towards Understanding Epigenetic Targets and Genotoxic and Mutagenic Biological Pathways of Azo Dyes within Organisms
Melissa A. Pasquinelli, (PI), NCSU
Rachelle Bienstock, (Co-I), NCSU

Impact of Phthalate Exposure on Paternal Programming of Offspring Neurological Phenotype
Emilie Rissman, (PI), NCSU
Sarah Robertson, (Co-I), Robinson Research Institute, Adelaide
John Schjenken, (Co-I), Robinson Research Institute, Adelaide

The Role and Regulation of p66Shc by Nrf2 in Cellular Antioxidant Response to Xenobiotics
Yoshiaki Tsuji, (PI), NCSU
Jun Ninomiya-Tsuji, (Co-I), NCSU
Masaki Miyazawa, (Co-I), NCSU

CHHE members and their students participated in NIEHS Fest in Durham this December.  NIEHS Fest was a celebration of NIEHS' fifty years of leadership in Environmental Health Science. For more information about NIEHS' anniversary events, go to:


2017 Burroughs Wellcome Distinguished Lecture
Dr. Robin D. Knight, University of California San Diego will present "Mapping Microbes on Scales from our Bodies to our Planet: From the Human Microbiome Project to the Earth Microbiome Project" on January 12, 2017, David Clark Labs Rm 101, 3:30 pm - 4:30 pm.

Dr. Rob Knight is a professor of pediatrics and computer science & engineering at the University of California, San Diego. His computational and experimental approaches have led to rapid and cost-effective microbial DNA sequencing methods and data analysis platforms that help to understand similarities among microbial communities based on their evolutionary relationships. Dr. Knight has used informatics to show how maps of distinct microbes thriving in different parts of the human body change over time, how human-associated microbes can influence metabolic health, and how microbes can be used as timekeepers to help establish the time of death in forensic examinations. As you will hear in his presentation, he has also set out to catalog the diverse kinds of microbes found in ecosystems across the globe in an ambitious, collaborative effort called the Earth Microbiome Project. Dr. Knight’s book Follow Your Gut was published in April 2015. He was also recently presented with the Vilcek Foundation Prize for Creative Promise in Biomedical Science for his groundbreaking research on microbial communities and the development of computational tools that honed the analysis of microbial data.
NIEHS Webinar on Ontologies, SEAZIT, and Zebrafish Screening Data.  NIEHS is  conducting a short webinar series that will provide an introduction to SEAZIT, ontologies, and application of ontologies to zebrafish screening data. The first webinar is February 2, 2017 at 11:30 am.  The link to sign up is here.
First Annual CHHE Science Symposium: February 16, 2017
Mark your calendars to attend the first annual CHHE Science Symposium - "Toxic Metals - From Exposures and Model Organisms to Human Populations" on February 16, 2017, Hunt Library, Duke Energy Hall AB 9:00 am - 5:00 pm. This year the symposium will feature research by CHHE members in the area of toxic metals from exposures to model organisms and human populations. Dr. Linda Birnbaum, Director of the National Institute of Environmental Health Sciences and the National Toxicology Program will provide opening remarks to kick off an exciting day of presentations and posters. Dr. Michael Waalkes, (NCI/NIEHS), a pioneering research scientist who has made seminal contributions to the toxic metal field will be the keynote speaker. Lorisa Seibel, Director of Housing Programs for Reinvestment Partners in Durham, NC, will discuss the impacts of toxic metals in our local community.  Presentations by CHHE members will highlight research expertise in the area of toxic metals involving ecotoxicology, remediation, exposures, susceptibility, model systems, genetics, and epidemiology. 

This event is open to anyone who would like to attend. CHHE members, their collaborators, graduate students and postdocs are encouraged to attend and present a poster on any aspect of their current research. 
Poster sessions will be open to all research areas and CHHE members as well as graduate students and post-docs.

Lunch will be provided, and there will be a reception with hors d’oeuvres and drinks at 5:00 pm. Registration is free and limited to the first 100 participants.
To register for the symposium, please visit,

The Brody School of Medicine, Department of Public Health at East Carolina University will be hosting, "Climate Change and Health: Focus on Eastern N.C." at the East Carolina Heart Institute on Thursday, March 23, 2017 at 9:00 am - 3:00 pm in Greenville

The purpose of the event is to raise awareness of climate change and health impacts on eastern North Carolina. The symposium aims to stimulate synergy and increase communication surrounding this issue among researchers, healthcare professionals, faculty, students and local community.  Faculty, students and researchers outside of ECU are welcome to attend.   
Invited speakers include representatives from the Centers for Disease Control and Prevention (CDC), US EPA, NC DHHS, Division of Public Health, Carolinas Health Care System, and The Southeast Regional Climate Center. The event is being co-sponsored by the gracious support of Clean Air Carolina, and NCSU Center for Human Health and the Environment (CHHE).  Lunch will be provided and pre-registration is required. Participants interested in presenting a poster are invited to submit an abstract through the registration website.
To register for the symposium, please visit, For more information, please contact Dr. Greg Kearney at ECU, Department of Public Health, at (252) 744-4039 or via email at

Associate Membership Available for Post-doctoral fellows: Postdocs and Research Associates with interests in Environmental Health Science can apply for Associate Membership in the Center. Prospective new members may self-nominate or be nominated by a CHHE member. The criteria for Associate Membership in the Center are: 1) Postdoc or Research Associate status at one of the CHHE partners; 2) significant interest in environmental health science; and 3) relevance of the individual’s research program to environmental health science.


John Meitzen won the National Award for Neuroscience Outreach. John has been named a 2016 recipient of the Society for Neuroscience’s (SfN) prestigious Next Generation Award. SfN is the largest international neuroscience society, with nearly 38,000 members. The Next Generation Award is a national honor that recognizes SfN members who have made outstanding contributions to public communication, outreach and education about neuroscience. Congratulations!

Matt Polizzotto and Jane Hoppin were part of a successful NCSU Research and Innovation Seeding Funding (RISF) application entitled Development of appropriate technologies to treat drinking water co-contaminants associated with chronic kidney disease with Detlef Knappe (engineering), Owen Duckworth (Soil Science) and James Harrington (RTI).  This project will be led by graduate student Maia Fitzsimmons (Soil Science) with potential application of water quality issues in developing countries.

Adrian Green, Tony Planchart's graduate student, received an SOT travel award to attend the 2017 annual meeting.  Congratulations!
Jennifer Runkle was the keynote speaker on 11/30 at East Carolina University's Symposium on Coastal Health Initiative.  David Collier, Jamie DeWitt and Suzanne Lea were presenters. 

Congratulations to Carolyn Mattingly and the whole Comparative Toxicogenomics Database (CTD) team!  The editors at Nucleic Acid Research (NAR) have selected CTD as one (of 110) of the "the golden set of databases that have consistently served as authoritative, comprehensive, and convenient data resources widely used by the entire community and offer some lessons on what makes a successful database.

Read full article here:

The "golden set" of 110 databases are listed in Table 3:

What makes a "good database"?  Read this section of paper:

COEC Update
Are you working on research that you think people outside your lab should know about? Do you want some help thinking of creative ways to communicate your research? Would you like to try and get more community groups and "regular people" involved in your research? The COEC is here to help!

In December, the COEC was busy working with other center members and our community partners in Durham. We held a community meeting before the holidays to talk about lead and cadmium exposure in Northeast Central Durham neighborhoods, and how to move forward with a collaborative research proposal between CHHE and the community. Close to 40 people attended and participated in the discussion!


PINS: Remember when submitting your grants, be sure to select "Center for Human Health and the Environment" as a center in PINS.

Acknowledgements: Remember to cite our CHHE grant P30ES025128 in publications if CHHE has provided you services, facility core use, seed/pilot project funds etc. NIH tracks this as an important CHHE metric.

CHHE Logo: Please use the CHHE logo in your presentations. You can find it on the

CHHE Resources and Facilities Page for NIH Grants is now available on the CHHE


Darryl Zeldin, NIEHS
"Thromboxane (TXA2) Attenuates Th9 Cell Differentiation and Function During Allergic Lung Inflammation"
January 24, 2017 Toxicology Building Auditorium 4:00 pm - 5:00 pm

Humphrey Hung-Chang Yao, NIEHS
"Sex, Arsenic, and Hedgehog: Mouse Models of Fetal Origins of Adult Diseases”
March 21, 2017 Toxicology Building Auditorium 4:00 pm - 5:00 pm

Rick Woychik, NIEHS
"Research Strategies for Exploring the Landscape of Environmental Health"
April 25, 2017 Toxicology Building Auditorium 4:00 pm - 5:00 pm

CHHE Calendar of events

CHHE Member Resources 
CHHE offers a host of resources for Center members: seed money for use in Facility Cores, Facility Cores for Pathology, Proteomics, Genomics, and Metabolomics, bioinformatic support, career development opportunities, travel funds, and more.  Check out the website for more details.  And, remember, if you take advantage of these resources be sure to cite the Center (P30ES025128) in the acknowledgments of papers.

Research Money for CHHE members: CHHE Seed Funds
CHHE is providing up to $5000/year to each CHHE member to defray the cost associated with using the Comparative Pathology Core (immunohistochemical staining , tissue embedding and processing, etc.) or the Systems Technologies Core, including the Genomics (RNAseq etc), Proteomics (targeted and discovery proteomics), and Metabolomics sections (analysis of endorgenous and exogenous compounds; metals, xenobiotics etc) for environmental health science related projects. CHHE will also consider providing funds to support EHS research associated with the Integrative Health Sciences Facility and Community Outreach and Engagement Cores. For more details, click on 

CHHE 2016 Travel/Workshop Award Announcement - - Rolling deadline
One of CHHE's missions is to support career development of new and early stage investigators. As part of the effort, CHHE will provide awards (up to $1,000) to help defray the cost of travel to scientific meetings or small symposia relevant to environmental health science or a workshop that will provide new skills. Travel/Workshop awards will be reviewed and prioritized by members of the 
Career Development Core. Your request should be succinct (less than 250 words) and document the importance of attending the requested meeting/workshop. Please aldo include the entire budget for travel/registration, etc. Please send your proposals to Jackie Broughton.

**See the for more information**

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Center for Human Health and the Environment · NC State University · Campus Box 7633 · Raleigh, NC 27607 · USA

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