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Vol. 2 No. 6 Sept 2016
Upcoming Events
 
9/12 - 10:00 am Molecular, Cellular-Based and Model Organisms (MSCMO) team to meet with Integrative Health Sciences Facility Core and Proteomics Core. Toxicology Building Auditorium
9/13 - 4:00 pm  CHHE/Toxicology co-sponsored seminar: Rodney Dietert, Cornell “Health Risks for the Human Superorganism” Toxicology Building Auditorium
9/14 - 9:00am Meeting with the University of Wollongong Researchers about collaborations
9/16 Abstracts due for NIEHS Fest
9/22 - 3:00 pm Media Training “Learn how to make the most of media opportunities to publicize your work” Toxicology Building Auditorium
9/24 - 4:00 pm CHHE/Toxicology co-sponsored seminar: Jodie Fleming, North Carolina Central University “The Role of the Lipolysis Stimulated Lipoprotein Receptor in the Promotion of Breast Cancer” Toxicology Building Auditorium
10/10 - 5:00pm Pilot Projects Due

Announcements 
CHHE is co-sponsoring two toxicology seminars in September: Rodney Dietert and Jodie Fleming.
  
On September 13th at 4:00pm, Rodney Dietert from Cornell University will deliver a seminar in the Toxicology Building Auditorium on the NCSU Centennial Campus entitled - “Health Risks for the Human Superorganism”. Dr. Dietert is a Professor in the Department of Microbiology and Immunology at Cornell. His research on the immune programming and the developmental basis of childhood and adult disease has been supported by the NSF, the USDA, the NIH and industry. Dr. Dietert is also the author of the book “The Human Superorganism: How the Microbiome is Revolutionizing the Pursuit of a Health Life”.


On September 27th at 4:00 pm, Jodie Fleming from North Carolina Central University will present a seminar in the Toxicology Building Auditorium on the NCSU Centennial Campus entitlted “The role of the Lipolysis Stimulated Lipoprotein Receptor in the promotion of breast cancer”. Dr. Fleming’s research is focused on the role of the tissue microenvironment in the development and progression of breast cancer.  She is a CHHE member and recent recipient of a CHHE Pilot Project grant to study the effect of silver nanoparticles on cell adhesion.

Visitors:  Professors Thomas Astell-Burt and Xiaoqi Feng from the University of Wollongong are coming to NC State, September 13-15 to discuss collaboration possibilities with CHHE members.  They are social epidemiologists interested in big data problems, so we're developing a project that will build on both their strengths and the strengths of CHHE.  They will be meeting with the Human Population Team and Bioinformatics Team on September 12 at 9 amto introduce their program and discuss possibilities.

NIEHS Fest: 
December 6-8, 2016,  NIEHS turns 50 this year and they are celebrating with a meeting in Durham in December.  The meeting is for scientists, students, post-docs, and community members.  It will be great if CHHE is well represented there. Registration is free and there's opportunities for poster and video presentations.  Registration is September 16, 2016.
 

Upcoming Career Development Opportunitites
 
Media Training:  It's exciting when a reporter calls to ask you about your work, but it also can be terrifying.  To learn how to navigate working with reporters, On Sept 22, at 3:00 pm in the Toxicology Building Auditorium, Tracey Peake from the NCSU Communications Office is going to offer a media training workshop for all interested CHHE members and their laboratories.  Learn how to make the most of media opportunities to publicize your work. In this 90-minute training session with experts from NC State's News Services group, we'll discuss how to develop mutually beneficial relationships with reporters, how to talk about your work in a way that captures media attention and how to prepare for a successful interview. Students and Post-docs are encouraged to attend. 

Grant writing workshop:  Want some help putting your first grant together, or just want some tips from a pro?  Ken Adler from CVM will lead a Grant Writing Workshop on Oct 12 in the Toxicology Building Auditorium.  More details to follow.

Individual Grant Writing Support:  Are you an early stage investigator putting together an environmental health science grant?  The Career Development Core is here to help. Director Chris McGahan can help you develop your specific aims, organize a mentoring committee, or a group for a chalk talk to help you crystallize your ideas.  Contact Chris to get started.

Associate Membership Available for Post-doctoral fellows: Postdocs and Research Associates with interests in Environmental Health Science can apply for Associate Membership in the Center. Prospective new members may self-nominate or be nominated by a CHHE member. The criteria for Associate Membership in the Center are: 1) Postdoc or Research Associate status; 2) significant interest in environmental health science; and 3) relevance of the individual’s research program to environmental health science.

Use Center Resources:  CHHE offers a host of resources for Center members: seed money for use in Facility Cores, Facility Cores for Pathology, Proteomics, Genomics, and Metabolomics, bioinformatic support, career development opportunities, travel funds, and more.  Check out the website for more details.  And, remember, if you take advantage of these resources be sure to cite the Center (P30ES025128) in the acknowledgments of papers.

Funding Resources
 
NIH has instituted a new policy on Authentication of Key Biological Resources.  Heather Patisaul has created a guide to the new NIH requirement.  As part of its efforts to improve transparency and reproducibility the NIH now requires a one page statement regarding the “Authentication of Key Biological Resources.” Grants evaluated in early 2016 were required to include this section but it did not impact scoring. Reviewers were asked to identify which proposals did the most effective job at completing this section. Based on information gained from CHHE members who participated in these discussions some tips and suggestions are provided on the website - click here

The Center for Human Heath and the Environment (CHHE) is announcing its request for applications (RFA) for pilot project proposals for 2016. Applications will be due on October 10th, 2016. The CHHE anticipates proposals from across the NCSU campus, ECU Brody School of Medicine, and NC Central University. The CHHE aims to enhance and integrate basic and translational research from molecules to cells to animal models to human populations using cutting-edge technologies and computational approaches to understand the impacts of environmental exposures/factors on human health. Individual awards will range upwards to $25,000 for one year.
To learn more and obtain pilot project application visit:
 https://chhe.research.ncsu.edu/pilot-projects/

The Research and Innovation Seed Funding (RISF) Program is now accepting proposals from NC State faculty and EPA research professionals. Due Date: Proposals are due Thursday, October 27, 2016, 5:00 P.M. The primary goal of the RISF program is to assist NC State researchers in developing innovative interdisciplinary programs that have strong potential for significant future external support from government agencies, corporations, industrial consortia or foundations.  Encouraged are projects that align with NC State’s strategic research areas of health and well-being, energy and environment, safety and security, or advanced materials and advanced manufacturing.  Proposed projects should be high risk/high gain and initiate new areas of research or enhance existing areas at NC State. Please visit website to learn more.

COEC Update

Community Outreach and Engagement Core

The COEC spent much of August working on the Community Mini Grant Program. We've had an overwhelming response to the program so far. Our grant-writing workshop had 23 participants, and when the call for applications closed on August 15, we had 40 great proposals to read. With the help of other Center members, we are in the process of reviewing proposals, providing lots of constructive feedback, and making some tough decisions, so that we can notify the chosen grantees by the middle of September. 
 

Reminders

PINS: Remember when submitting your grants, be sure to select "Center for Human Health and the Environment" as a center in PINS.

Acknowledgements: Remember to cite our CHHE grant P30ES025128 in publications if CHHE has provided you services, facility core use, seed/pilot project funds etc. NIH tracks this as an important CHHE metric.

CHHE Logo: Please use the CHHE logo in your presentations. You can find it on the
website 

CHHE Resources and Facilities Page for NIH Grants is now available on the CHHE
website.

Seminars

Seminars: Send Jackie seminar announcements/events etc. for the CHHE calendar.

Rodney Dietert, Cornell University 

“Health Risks for the Human Superorganism”
September 13, 2016 Toxicology Building Auditorium 4:00 pm - 5:00 pm

Jodie Fleming, North Carolina Central University

 “The Role of the Lipolysis Stimulated Lipoprotein Receptor in the Promotion of Breast Cancer”
September 21, 2016 Toxicology Building Auditorium 4:00 pm - 5:00 pm


 

Kudos 
CHHE members in the news:
Jane Hoppin was interviewed by WUNC about her paper on pesticides and wheeze.  
Ken Adler appeared on CBS News about his work on a cancer drug that blocks a specific protein. Learn more
here.
Heather Patisaul was quoted in
Time about endocrine disruptors 

Trudy Mackay and Chris McGahan were elected for membership in
NC State's Research Leadership Academy.

Ross Meentemeyer was elected President of the US International Association on Landscape Ecology


Chris Frey and colleagues monitor air quality during and after tailgating.  Read more here.

New Members
Associate Member:
Marine Baptissart, Postdoctoral Research Scholar - Dept. of Biological Sciences, NCSU

CHHE Member Resources 
 
The CHHE has cores for members to use to enhance their research. Seed money is available to members to spend in the cores.  These cores are:

The Comparative Pathology Core  provides pathology training, laser capture microdissection and pathology assessment of a diverse range of model organisms as well consultation
and opportunities for collaboration.


The Integrative Health Science Facility Core can help you translate your findings from animal/cell models to humans or vice versa.  This core can help you obtain human tissues/specimens, help with conduct of human studies (questionnaire development, IRB assistance), use of the comparative toxicogenomic database (CTD, ctdbase.org) either with specialized training or data curation, access to clinical populations at ECU, and much more.

The Systems Technologies Core provides genomic, metabolomics and proteomic analysis as well as consultation and opportunities for collaboration.

Dedicated Bioinformatic support is available for CHHE members.

Career Development Core provides grant writing help to early stage investigators and those new to environmental health sciences research. This core also provides funding for early stage investigators to attend a scientific meeting/workshop. 

 
Community Outreach and Engagement Core (COEC) extends the reach of our research to communities in NC and beyond. The COEC can help you translate your research findings for the general public.

Research Money for CHHE members: CHHE Seed Funds
CHE is providing up to $3000/year to each CHHE member to defray the cost associated with using the Comparative Pathology Core (immunohistochemical staining , tissue embedding and processing, etc.) or the Systems Technologies Core, including the Genomics (RNAseq etc), Proteomics (targeted and discovery proteomics), and Metabolomics sections (analysis of endorgenous and exogenous compounds; metals, xenobiotics etc) for environmental health science related projects. CHHE will also consider providing funds to support EHS research associated with the Integrative Health Sciences Facility and Community Outreach and Engagement Cores. For more details, click on 
link.


SEED Projects with the NIH Common Fund Metabolomics Core at RTI
One of the CHHE partners is the Metabolomics Core at RTI. This Core serves as the NIH Common Fund Eastern Regional Comprehensive Metabolomics Resource Core (ERCMRC), and as a NIEHS Children’s Exposure Analysis Resource (CHEAR) Hub. Researchers at RTI are interested in collaborating with CHHE members to conduct pilot studies to measure environmentally relevant compounds, and perform metabolomics analysis of cells, tissue, and biological fluids.
Contact
Susan Sumner to discuss potential projects that can be funded through the  ERCMRC at RTI.  Selected Seed projects would be performed for studies involving up to 50 samples, with preliminary data used for subsequent proposal submissions.

CHHE 2016 Travel/Workshop Award Announcement - - Rolling deadline
One of CHHE's missions is to support career development of new and early stage investigators. As part of the effort, CHHE will provide awards (up to $1,000) to help defray the cost of travel to scientific meetings or small symposia relevant to environmental health science or a workshop that will provide new skills. Travel/Workshop awards will be reviewed and prioritized by members of the 
Career Development Core. Your request should be succinct (less than 250 words) and document the importance of attending the requested meeting/workshop. Please aldo include the entire budget for travel/registration, etc. Please send your proposals to Jackie Broughton.


The National Children’s Study in the United States has expanded access to its data
As of March 1, 2016, the National Children's Study (NCS) in the United States has expanded access to its Vanguard Data and Sample Archive (
NCS Archive). The NCS Vanguard was a pilot for a planned cohort study of environmental influences on child health and development. Starting in 2009, recruitment strategies were tested in 43 counties across 31 states throughout the U.S. The Vanguard study enrolled over 5,600 birth families and followed them through 2014. Qualified investigators can now petition to access the questionnaires and interviews; neuro-psychosocial and cognitive assessments; and physical examination data, along with nearly 25,000 biological and environmental primary samples. You can read more about this program here
**See the http://chhe.research.ncsu.edu/ for more information**

Recent CHHE Publications
 
Obp56h Modulates Mating Behavior in Drosophila melanogaster.
By: Shorter, JR; Dembeck, LM; Everett, LJ; Morozova, TV; Arya, GH; Turlapati, L; St Armour, GE; Schal, C.; Mackay, TF; Anholt, RR.
G3 (Bethesda). 2016 Aug 24. pii: g3.116.034595. doi: 10.1534/g3.116.034595. [Epub ahead of print]
 

An Inhaled Inhibitor of MARCKS Reverses LPS-induced Acute Lung Injury in Mice.
By: Yin, Q.; Fang, S.; Park, J.; Crews, AL.; Parikh, I.; Adler, KB.
Am J Respir Cell Mol Biol. 2016 Aug 24. [Epub ahead of print]
 

Whole-Genome Sequences of Agricultural, Host-Associated Campylobacter coli and Campylobacter jejuni Strains.
By: Dutta, V.; Altermann, E.; Olson, J.; Wray, GA; Siletzky, RM; Kathariou, S.
Genome Announc. 2016 Aug 18;4(4). pii: e00833-16. doi: 10.1128/genomeA.00833-16.
 

"Spatial Energetics": Integrating Data From GPS, Accelerometry, and GIS to Address Obesity and Inactivity.
By: James, P.; Jankowska, M.; Marx, C.; Hart, JE; Berrigan, D.; Kerr, J.; Hurvitz, PM; Hipp, JA; Laden, F.
Am J Prev Med. 2016 Aug 12. pii: S0749-3797(16)30227-6. doi: 10.1016/j.amepre.2016.06.006. [Epub ahead of print]
 

Evaluation of artificial selection in Standard Poodles using whole-genome sequencing.
By: Friedenberg, SG; Meurs, KM; Mackay, TF.
Mamm Genome. 2016 Aug 10. [Epub ahead of print]
 

Isolation and characterization of atypical Listeria monocytogenes associated with a canine urinary tract infection.
By: Palerme, JS; Pan, PC; Parsons, CT; Kathariou, S.; Ward, TJ; Jacob, ME.
J Vet Diagn Invest. 2016 Sep;28(5):604-7. doi: 10.1177/1040638716661381. Epub 2016 Aug 4.
 

A validated protocol to quantify severity of male urogenital feminization using the MOUSE (Mouse objective urethral severity evaluation).
By: Amato, CM; McCoy, KA.
Pediatr Res. 2016 Aug 4. doi: 10.1038/pr.2016.157. [Epub ahead of print]
 

Quantitative analysis of B-lymphocyte migration directed by CXCL13.
By: Liu, X.; Asokan, SB; Bear,JE; Haugh, JM.
Integr Biol (Camb). 2016 Aug 8;8(8):894-903. doi: 10.1039/c6ib00128a. Epub 2016 Aug 1.


Chemical controls on abiotic and biotic release of geogenic arsenic from Pleistocene aquifer sediments to groundwater.
By: Gillispie, EC.; Andujar, E.; Polizzotto, ML.
Environ Sci Process Impacts. 2016 Aug 10;18(8):1090-103. doi: 10.1039/c6em00359a.
  

Still Separate, Still Unequal: Social Determinants of Playground Safety and Proximity Disparities in St. Louis.
By: Arroyo-Johnson, C.; Woodward, K.; Milam, L.; Ackermann, N.; Komaie, G.; Goodman, MS; Hipp, JA.
J Urban Health. 2016 Aug;93(4):627-38. doi: 10.1007/s11524-016-0063-8.
 

Sharing the Roles: An Assessment of Japanese Medaka Estrogen Receptors in Vitellogenin Induction.
By: Lee Pow, CS; Yost, EE; Aday, DD; Kullman, SW.
Environ Sci Technol. 2016 Aug 16;50(16):8886-95. doi: 10.1021/acs.est.6b01968. Epub 2016 Jul 26.
 

Neonatal Masculinization Blocks Increased Excitatory Synaptic Input in Female Rat Nucleus Accumbens Core.
By: Cao, J.; Dorris, DM.; Meitzen, J.
Endocrinology. 2016 Aug;157(8):3181-96. doi: 10.1210/en.2016-1160. Epub 2016 Jun 10.
 

Autosomal recessive congenital ichthyosis due to PNPLA1 mutation in a golden retriever-poodle cross-bred dog and the effect of topical therapy.
By: Tamamoto-Mochizuki, C.; Banovic, F.; Bizikova, P.; Laprais, A.; Linder KE; Olivry T.
Vet Dermatol. 2016 Aug;27(4):306-e75. doi: 10.1111/vde.12323. Epub 2016 May 30.
 

Genomic Prediction for Quantitative Traits Is Improved by Mapping Variants to Gene Ontology Categories in Drosophila melanogaster.
By: Edwards, SM; Sørensen, IF; Sarup, P; Mackay, TF; Sørensen P.
Genetics. 2016 Aug;203(4):1871-83. doi: 10.1534/genetics.116.187161. Epub 2016 May 27.
 

Laboratory and Field Evaluation of Zyrox Fly Granular Bait Against Asian and German Cockroaches (Dictyoptera: Blattellidae).
By: Matos, YK; Schal C.
J Econ Entomol. 2016 Aug;109(4):1807-12. doi: 10.1093/jee/tow092. Epub 2016 Apr 27.
 

Impact of Environmental Chemicals on the Transcriptome of Primary Human Hepatocytes: Potential for Health Effects.
By: Mitchell, RD 3rd; Dhammi, A.; Wallace, A,; Hodgson E.; Roe RM.
J Biochem Mol Toxicol. 2016 Aug;30(8):375-95. doi: 10.1002/jbt.21801. Epub 2016 Apr 19.
 

The Endocrine Society Centennial: No Longer a Surprise: Estrogenic Chemicals in a Multitude of Places
By: Rissman, Emilie F.
ENDOCRINOLOGY Volume: 157 Issue: 8 Pages: 2969-2971 Published: AUG 2016
  

Biodiversity gradients in obligate symbiotic organisms: exploring the diversity and traits of lichen propagules across the United States
By: Tripp, Erin A.; Lendemer, James C.; Barberan, Albert; Dunn, Robert; et al.
JOURNAL OF BIOGEOGRAPHY Volume: 43 Issue: 8 Pages: 1667-1678 Published: AUG 2016
 

Health effects following subacute exposure to geogenic dusts from arsenic-rich sediment at the Nellis Dunes Recreation Area, Las Vegas, NV
By: DeWitt, Jamie; Buck, Brenda; Goossens, Dirk; et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY 
Volume: 304 Pages: 79-89 Published: AUG 1 2016

 






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