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Vol. 2 No.1 April 2016
Upcoming Events

April 8, 2016 CHHE Retreat
12:00-6:00 JC Raulston Arboretum
RSVP to
Jackie Broughton

April 19, 2016 Dana Dolinoy, University of Michigan
"Perinatal Environmental Exposures: Effects on Metabolic Homeostasis and the Epigenome"
4:00 pm Toxicology Building Auditorium

May 11, 2016 IPA Introduction & Hands-On Training
10 am to 12:00 pm
Toxicology Auditorium

Announcements
 
April 8, 2016 CHHE Retreat
Come join us for the 2nd CHHE retreat on April 8, 2016 at the Arboretum (directions, 12-6 pm).  Join your fellow CHHE members for lunch and updates about the Center's activities.  Learn about the activities of the Community Outreach and Engagement Core.  Hear updates from the pilot projects.  Connect with others about potential future research in environmental health sciences.  Bring your walking shoes.  If it's a nice day, we promise to get you outside!  RSVP to Jackie Broughton.

April 1, 2016 Dana Dolinoy, University of Michigan
"Perinatal Environmental Exposures: Effects on Metabolic Homeostasis and the Epigenome"
The Dolinoy Lab investigates environmental epigenetics and gene-environment interactions using animal models, human clinical samples, and human population studies. Specifically, research focuses on nutrition and environmental chemicals and how many common compounds, such as bisphenol A (BPA), may have deleterious physiological consequences through abnormal epigenetic and genetic regulation.
4:00 pm Toxicology Building Auditorium

 
Event of Interest: NIH Transgenerational Workshop - April 21-22, 2016
https://tools.niehs.nih.gov/conference/transgenerational_2016/


May 11, 2016 IPA Introduction & Hand-On Training
Ingenuity Pathway Analysis (IPA) is an all-in-one software application that enables you to analyze, integrate and understand complex data such as those derived from proteomics, metabolomics and RNAseq experiments.  IPA allows you to build interactive models of your experimental system.This hands-on training session will mainly focus on biological interpretation of expression data. Using IPA you will learn how to rapidly understand:pathway involvement and change, effected biological processes, causal regulators and their directional effect on genes, functions and diseases across multiple time points or doses. You will also learn to explore IPA's knowledge &discovery tools that allow you to relate the mostrecent literature findings to your research. Bring your laptops. There will be afternoon sessions on more advanced topics. 10 am - 12 pm, Toxicology Auditorium. 

June 19-24, 2016 Heather Patisaul is organizing a Gordon Conference on Environmental Endocrine Disruptors:  “The Next Generation of Endocrine Disruption: Emerging Contaminants, Tools and Research Approaches for Assessing Multigenerational Effects”.  It’s co-sponsored by NC State, NIEHS, and EPA. David Aylor is one of the invited speakers.  The link to register is here: To Register please visit https://www.grc.org/programs.aspx?id=12743 

Kudos
 
Congratulations to CHHE’s Career Development Core Leader Chris McGahan and Trudy MacKay for being selected for the NC State Research Leadership Academy and receiving the 2014-2015 Alumni Association Outstanding Research Award!
 
Congratulations to Comparative Pathology Core Associate Director Heather Shive on her newly awarded K01 award “Identification of genetic collaborators in cancer with a brca2-mutant zebrafish model.” The major goals of this project are to identify and functionally characterize conserved cancer-associated candidate genes linked to BRCA2 mutation with the zebrafish model, which are directly testable in this model for their potential contributions to cancer development.
 
Katie Hudson (graduate student in the Mike Cowley's Lab) has received a 2016 Provost Research Award in the amount of $10,000 for her project "Role of Sp1 in cadmium-induced DNA methylation changes". Cadmium is known to impact DNA methylation, but its modes of action are unclear. Katie will test the hypothesis that binding of the transcription factor Sp1 to DNA methyltransferase genes is inhibited by cadmium, and that this affects the expression of these genes, potentially explaining alterations to DNA methylation.
 
Jun Ninomiya-Tsuji’s doctoral student Yosuke Sakamachi was awarded ASBMB (American Society of Biochemistry and Molecular Biology) travel award for presenting his poster in ASBMB 2016 Annual Meeting at San Diego, April 2-6, 2016.
 
Heather Patisaul spoke at RTP 180 about her work and her relationship to NIEHS.  The RTP 180 series, with a focus on the emerging technologies and trends, attracts employees of the high tech, biotech, pharmaceutical, and other companies located in RTP. Susan Sumner also participated in this event.  A link to video is here.
https://www.youtube.com/watch?v=MMmNrPdM9lM&list=PLQWg0VBT7RCC7LgH_8-sevgkl7Zfq-yQL&index=5.  This is part of the celebration of 50 years of NIEHS.  A link to all events is here.  http://www.niehs.nih.gov/about/anniversary/index.cfm

 
***Send your Kudos to Jane Hoppin every month***

Society of Toxicology Meeting, March 2016

CHHE was well represented at the Society of Toxicology meeting this March.
 
David Aylor gave a platform presentation on Differential susceptibility to diethylstilbestrol exposure in genetically diverse mice.
 
Tony Planchart gave an Advanced Continuing Education talk on The ins and outs of using zebrafish for mechanistic toxicology studies.

Kym Gowdy, ECU, received a CHHE travel award to present her work:  Scavenger receptor BI regulates pulmonary inflammation after ozone exposure.”

David Reif gave a platform presentation on Leveraging High-Dimensional Data to Inform Probabilistic Dose-Response Estimates.
 
Gina Hilton, a toxicology graduate student working with Michael Bereman and Jamie Bonner, presented a poster on Identification of Biomarkers for Nano-safety Assessment through Proteomic Analysis of Multi-Walled Carbon Nanotubes Functionalized by Atomic Layer Deposition Coating both at SOT and the NC SOT, where she took 2nd place for her poster.  Congratulations Gina!

 
SOT Abstracts from CHHE members and their students

Zusanna Drobna’s group
 
Association between variants in arsenic (+3 oxidation state) methyltransferase (AS3MT) and urinary metabolites of inorganic arsenic: role of exposure level. Xu, X., Drobna, Z., Voruganti, S., Barron, K., Gonzalez-Horta, C., Sanchez-Ramirez, B., Ballinas-Casarubias, L., Hernandez Ceron, R., Viniegra Morales, D., Baeza Terrazas, F.A., Ishida, M.C., Gutierrez-Torres, D.S., Saunders, R.J., Fry, R.C., Loomis, D., Garcia-Vargas, G.G., Del Razo, L.M., Styblo, M., Mendez, M.A.
 
Urinary metabolomic shifts in pregnant women exposed to arsenic.
Bailey, K.A., Sebastian, E., Laine, J., Olshan, A., Smeester, L., Drobna, Z., Styblo, M., Rubio-Andrade, M., Garcia-Vargas, G., Fry, R.C.
 
Maternal genotype for arsenic (+3 oxidation State)-methyltransferase influences inorganic arsenic metabolism and newborn birth outcomes in a pregnancy cohort in Mexico.  Drobna, Z., Martin, E., Rubio-Andrade, M., Garcia-Vargas, G.G., Styblo, M., Su Kim, K., Zou, F., Fry, R.C.
 
DNA  methylation characteristics of arsenic-associated diabetes in a prospective cohort in Chihuahua, Mexico Martin, E., Bailey, K., Smeester, L., Gonzalez-Horta, C., Sanchez Ramirez, B., Ballinas-Casarubias, L., Ishida, M., Guitierrez-Torres, D., Hernandez Ceron, R., Viniegra Morales, D., Baeza Terrazas, F.,  Del Razo, L.M., Garcia-Vargas, G.G., Buse, J., Loomis, D., Drobna, Z., M., Styblo, M., Fry, R.C.

Seth Kullman's group


Validation Of High-throughput Screening Data And Novel Mechanistic Insights Into Vdr-xenobiotic Interactions By Orthogonal Assays. Mahapatra, D., Franzosa, J.A., Houck, K.A., Kullman, S.W.
 
Carolyn Mattingly and Tony Planchart’s groups
 
Integration of Tox21 and CTD Data: Elucidating Correlations between High-Throughput Chemical Screening and Curated Literature. Collier, G., Planchart, A., Reif, D.M., Mattingly, C.J.
 
The Anti-Rheumatic Drug, Leflunomide, Implicates the Aryl Hydrocarbon Receptor in Altered Dopaminergic Biology
Cook, E., Mattingly, C.J., Planchart, A.
 
Perinatal Exposure to the Flame Retardant Triphenyl Phosphate Accelerates Type 2 Diabetes and Causes Obesity in
UCD-T2DM Rats. Green, A.J., Graham, J.L., Cano-Sancho, G., Gonzalez, E.A., Havel, P.J., La Merrill, M.A.
 
The Comparative Toxicogenomics Database (CTD): Expanding Exposome and Phenotype Content to Elucidate Chemical-Disease Relationships. Mattingly, C.J., Grondin, R., Johnson, D., Sciaky, B.L., King, J., Wiegers, T.C. and  Davis, A.P.
 
David Reif’s group
 
Using ToxPi to Determine Biological Activity and Toxicity of Chemicals Present at Superfund Sites in North Carolina.
Tilley, S.K., Nguyen, A., To, K., Reif, D.M., Fry, R.C.
 
Elucidating Gene by Environment Interactions (GxE) Associated with Interindividual Variation in Response to Chemical Exposure. Meisner, M., Truong, L., Tanguay, R.L., Reif, D.M.
 
A New Statistical Approach to Characterize Chemical-Elicited Effects in Behavioral Data from High-Throughput Studies of Zebrafish Exposed to Diverse Chemicals. Zhang, G., Truong, L., Tanguay, R.L., Reif, D.M.
 
Handling Missing Data in Chemical Prioritization and Bioactivity Profiling Applications Using ToxPi. To, K., Nguyen, A., Fry, R.C., Reif, D.M.
 
Zebrafish High-Throughput Data Analysis and Quality Control Pipeline. Marvel, S., Truong, L., Tanguay, R.L., Reif, D.M.
 
Quantification and Genetic Components of Synergistic Interactions among Anticancer Drugs in Lymphoblastoid Cell Lines. Roell, K.R., Havener, T.M., Jack, J.R., McLeod, H.L., Reif, D.M., Motsinger-Reif, A.A.
 
Use of High Throughput Screening Data in IARC Monograph Evaluations. Rusyn, I., Chiu, W., Guyton, K., Martin, M., Reif, D.M.
 
Leveraging High-Dimensional Data to Inform Probabilistic Dose-Response Estimates. Reif, D.M.

Categorization of UVCBs Using Chemical-Biological Read Across. 
Grimm, F.A., Iwata, Y., Sirenko, O., Russell, W.K., Luo, Y.S., Crittenden, C., Wright, F. A., Reif, D.M., Yeakley, J., Seligmann, B., Shepard, P., Roy, T., Boogaard, P.J., Ketelslegers, H., Rohde, A.M., Rusyn I. 

COEC Update

Community Outreach and Engagement Core

March was a busy month for the COEC! Katy May and Cathrine Hoyo met with board members from Partnership Efforts for the Advancement of Children's Health( PEACH) in Durham to discuss research findings, and brainstorm ways to engage the community in risk reduction actions for toxic metals.
 
Catherine LePrevost continued her work related to farmworker health, conducting a focus group with outreach workers in Prospect Hill, and presenting the Pesticides and Farmworker Health Toolkit to migrant head start centers in RTP. 

On March 10 the COEC, along with David Collier, facilitated a meeting on water quality issues facing eastern North Carolina, engaging a diverse group of twenty stakeholders.

The COEC team held its final focus group for its fish consumption advisory project in Caldwell County on March 29. Ten 
fishermen participated to discuss ways to improve the communication of advisories. 

The COEC devoted a lot of time and effort this month to getting its portion of the larger CHHE website, and all the social media platforms ready to go public. All the sites, along with various photos, videos, and blog posts will be revealed at the Center retreat. 

Funding Opportunities 
 
Acknowledgements: Remember to cite our CHHE grant P30ES025128 in publications if CHHE has provided services, facility core use, seed/pilot project funds etc. NIH tracks this as an important CHHE metric. "Research reported in this publication was supported NIEHS under award number P30ES025128 Center for Human Health and the Environment.".

University Global Partners Network www.ugpn.org has a call for proposals for collaboration with NC State sister institutions (University of Sao Paulo, Brazil; University of Surrey, UK; and University of Woolongong, Australia).  Researchers in Australia are particularly interested in collaborating with CHHE members.  Proposals are due May 3, 2016.  See details here: http://www.ugpn.org/Research/
 
NC State Office of Research, Innovation, and Economic Development has announced a new program GRIP (Game-Changing Research Incentive Program).  Pre-proposals due May 31, 2016
GRIP will allocate more than $1,500,000 over three years to fund exceptional research teams and projects that span NC State colleges. GRIP is intended to incentivize and support visionary research ideas that will result in large-scale extramural funding, award-winning research impacts, and first-class interdisciplinary graduate education and training. For more information about GRIP (including a copy of the RFP and a short video about the program) please visit https://research.ncsu.edu/rdo/funding/internal-funding/grip/.
 
Integrating Human Health and Well-Being with Ecosystem Services 
URL: 
http://www.epa.gov/research-grants/integrating-human-health-and-well-being-ecosystem-services 

Open Date: 02/22/2016 - Close Date: 04/21/2016 
The U.S. Environmental Protection Agency (EPA) announces the release of the Integrating Human Health and Well-Being with Ecosystem Services Request for Applications.  This RFA goal is to fund community-based research that will foster better understanding of how human health and well-being are interconnected with—and depend on—ecosystem services. Specifically, this research examines how communities can integrate ecosystem services with human health and well-being to inform their decision making and management practices. This RFA aims to develop information that allows communities to integrate environmental, societal and economic information and to better manage multiple stressors and their cumulative impacts on humans and ecosystems. The ultimate goal is to help communities achieve their own objectives while taking advantage of more relevant and accessible information about ecosystem services. The Integrating Human Health and Well-Being with Ecosystems Services RFA is part pf EPA’s Sustainable and Healthy Communities (SHC) Research program. The SHC Research Program provides useful science and tools for decision makers at all levels to help communities advance sustainability as well as achieve regulatory compliance.  SHC is collaborating with partners to conduct research that will result in science-based knowledge to guide decisions that will better sustain a healthy society and environment in America's communities. Partnerships and community engagement are strongly encouraged for this research.

Reminders

PINS: Remember when submitting your grants, be sure to select "Center for Human Health and the Environment" as a center in PINS.

Research Teams are meeting to discuss topics to work on together and what types of events/enrichment activities they would like CHHE to offer.

Acknowledgements: Remember to cite our CHHE grant P30ES025128 in publications if CHHE has provided you services, facility core use, seed/pilot project funds etc. NIH tracks this as an important CHHE metric.

CHHE Logo: Please use the CHHE logo in your presentations. You can find it on the
website 

CHHE Resources and Facilities Page for NIH Grants is now available on the CHHE
website.

Seminars

Upcoming CHHE Seminars:

Dana Dolinoy - University of Michigan - "Perinatal Environmental Exposures: Effects on Metabolic Homeostasis and the Epigenome". April 19, 2016  4:00 pm - Toxicology Building Auditorium.
 
Seminars: Send Jackie seminar announcements/events etc. for the CHHE calendar.

CHHE Member Resources 
 
The CHHE has cores for members to use to enhance their research. Seed money is available to members to spend in the cores.  These cores are:

The Comparative Pathology Core  provides pathology training, laser capture microdissection and pathology assessment of a diverse range of model organisms as well consultation
and opportunities for collaboration.


The Integrative Health Science Facility Core can help you translate your findings from animal/cell models to humans or vice versa.  This core can help you obtain human tissues/specimens, help with conduct of human studies (questionnaire development, IRB assistance), use of the comparative toxicogenomic database (CTD, ctdbase.org) either with specialized training or data curation, access to clinical populations at ECU, and much more.

The Systems Technologies Core provides genomic, metabolomics and proteomic analysis as well as consultation and opportunities for collaboration.

Dedicated Bioinformatic support is available for CHHE members.

Career Development Core provides grant writing help to early stage investigators and those new to environmental health sciences research. This core also provides funding for early stage investigators to attend a scientific meeting/workshop. 

 
Community Outreach and Engagement Core (COEC) extends the reach of our research to communities in NC and beyond. The COEC can help you translate your research findings for the general public.

Research Money for CHHE members: CHHE Seed Funds
CHE is providing up to $3000/year to each CHHE member to defray the cost associated with using the Comparative Pathology Core (immunohistochemical staining , tissue embedding and processing, etc.) or the Systems Technologies Core, including the Genomics (RNAseq etc), Proteomics (targeted and discovery proteomics), and Metabolomics sections (analysis of endorgenous and exogenous compounds; metals, xenobiotics etc) for environmental health science related projects. CHHE will also consider providing funds to support EHS research associated with the Integrative Health Sciences Facility and Community Outreach and Engagement Cores. For more details, click on 
link.

CHHE 2016 Travel/Workshop Award Announcement - - Rolling deadline
One of CHHE's missions is to support career development of new and early stage investigators. As part of the effort, CHHE will provide awards (up to $1,000) to help defray the cost of travel to scientific meetings or small symposia relevant to environmental health science or a workshop that will provide new skills. Travel/Workshop awards will be reviewed and prioritized by members of the 
Career Development Core. Your request should be succinct (less than 250 words) and document the importance of attending the requested meeting/workshop. Please aldo include the entire budget for travel/registration, etc. Please send your proposals to Jackie Broughton.


 
**See the http://chhe.research.ncsu.edu/ for more information**

CHHE Publications
 
Spatio-temporal reconstruction of missing forest microclimate measurements
Tonini, F., Dillon, W.W., Money, E.S., Meentemeyer, R.K., et al.
AGRICULTURAL AND FOREST METEOROLOGY Volume: 218 Pages: 1-10 Published: MAR 15 2016
 

Noise exposure assessment among groundskeepers in a university setting: A pilot study
Balanay, J.G., Kearney, G.D., Mannarino, A.J.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE Volume: 13 Issue: 3 Pages: 193-202
 

Thermal reactionomes reveal divergent responses to thermal extremes in warm and cool-climate ant species
Stanton-Geddes, J., Nguyen A., Chick, L., Dunn, R.R., et al.

Real-world activity, fuel use, and emissions of diesel side-loader refuse trucks
Sandhu, G.S., Frey, H.C., Bartelt-Hunt, S., et al.
ATMOSPHERIC ENVIRONMENT Volume: 129 Pages: 98-104 Published: MAR 2016
 

Urban stress is associated with variation in microbial species composition-but not richness-in Manhattan
Reese, A.T., Savage, A., Youngsteadt, E., Dunn, R.R., et al.
 

Gene expression in major depressive disorder
Jansen, R., Penninx, B.W., Madar, V., Wright, F.A., et al.
MOLECULAR PSYCHIATRY Volume: 21 Issue: 3 Pages: 339-347 Published: MAR 2016
 

Integrative approaches for large-scale transcriptome-wide association studies
Gusev, A., Ko, A., Shi, H., Wright, F.A., et al.
NATURE GENETICS Volume: 48 Issue: 3 Pages: 245-252 Published: MAR 2016
 

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease.
Bogdan, A.R., Miyazawa, M., Hashimoto, K., Tsuji, Y., et al.
Trends in biochemical sciences Volume: 41 Issue: 3 Pages: 274-86 Published: 2016-Mar (Epub 2015 Dec 23)
 

Urinary Concentrations of Phthalate Metabolites and Bisphenol A and Associations with Follicular-Phase Length, Luteal-Phase Length, Fecundability, and Early Pregnancy Loss
Jukic, A.M., Calafat, A.M., McConnaughey, D.R., Hoppin, J.A., et al.
ENVIRONMENTAL HEALTH PERSPECTIVES Volume: 124 Issue: 3 Pages: 321-328 Published: MAR 2016


Organic Food Consumption during Pregnancy and Hypospadias and Cryptorchidism at Birth: The Norwegian Mother and Child Cohort Study (MoBa)
Brantsaeter, A.L., Torjusen, H., Meltzer, H.M., Hoppin, J.A., et al.
ENVIRONMENTAL HEALTH PERSPECTIVES Volume: 124 Issue: 3 Pages: 357-364 Published: MAR 2016
 

Salinized rivers: degraded systems or new habitats for salt-tolerant faunas?
Kefford, B.J., Buchwalter, D., Canedo-Arguelles, M., et al.
Biology letters Volume: 12 Issue: 3 Published: 2016-Mar
 

Integrative and comparative reproductive biology: From alligators to xenobiotics.
McCoy, K.A., Roark, A.M., Boggs, A.S., Bowden, J.A., Cruze, L., Edwards, T.M., Hamlin, H.J., Cantu, T.M., McCoy, J.A., McNabb, N.A., Wenzel, A.G., Williams, C.E., Kohno, S.
Gen Comp Endocrinol. 2016 Mar 21.
 

Genetic Background, Maternal Age and Interaction Effects Mediate Rates of Crossing over in Drosophila melanogaster Females.
Hunter, C.M., Robinson, M.C., Aylor, D.L., Singh, N.D.
G3 (Bethesda). 2016 Mar 18.
 

TAK1 determines susceptibility to endoplasmic reticulum stress and hypothalamic leptin resistance.
Sai, K., Morioka, S., Takaesu, G., Muthusamy, N., Ghashghaei, H.T., Hanafusa, H., Matsumoto, K., Ninomiya-Tsuji, J.
J Cell Sci. 2016 Mar 16.
 

TAK1 regulates hepatic lipid homeostasis through SREBP.
Morioka, S., Sai, K., Omori, E., Ikeda, Y., Matsumoto, K., Ninomiya-Tsuji, J.
Oncogene. 2016 Mar 14.
 

Reduced cellular immune response in social insect lineages.
López-Uribe, M.M., Sconiers, W.B., Frank, S.D., Dunn, R.R., Tarpy, D.R.
Biol Lett. 2016 Mar; 12(3).
 
 
TransOmic analysis of forebrain sections in Sp2 conditional knockout embryonic mice using IR-MALDESI imaging of lipids and LC-MS/MS label-free proteomics.
Loziuk, P., Meier, F., Johnson, C., Ghashghaei, H.T., Muddiman, D.C.
Anal Bioanal Chem. 2016 Mar 4.
 

Frogs as integrative models for understanding digestive organ development and evolution.
Womble, M., Pickett, M., Nascone-Yoder, N.
Semin Cell Dev Biol. 2016 Mar; 51:92-105.






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