Vol. 2 No. 12 March 2017          
Upcoming Events

Cancelation of CHHE Retreat on April 21, 2017
Due to same day conflicts with Keck Center Symposium and the State of the Sciences at the Hunt Library, we decided to move the CHHE retreat to sometime in the Fall. 

3/21 - CHHE/Toxicology Co-sponsored Seminar
Humphrey Hung-Chang Yao, NIEHS
"Sex, Arsenic, and Hedgehog: Mouse Models of Fetal Origins of Adult Diseases"
Toxicology Building Auditorium 4:00 pm - 5:00 pm

3/23 - East Carolina University's Climate Change and Health Conference
"Climate Change and Health: Focus on Eastern N.C."
9:00 am - 3:00 pm
East Carolina Heart Institute
East Carolina University

CHHE Symposium was a great success! 

CHHE held its first annual science symposium on February 16th, 2017 at the James B. Hunt Library. The event, “Toxic Metals – From Exposures and Model Systems to Human Populations,” was designed to bring center members and colleagues together for one day to highlight CHHE research on a given scientific theme. More than 100 investigators, postdocs, graduate students and community members attended to participate in scientific talks, present at poster sessions and socialize with colleagues.

NIEHS Director Dr. Linda Birnbaum kicked off the event with a talk highlighting the importance of toxic metal exposure science and recent NIEHS-funded discoveries in the field. Lorisa Seibel, Director of Housing Programs for Reinvestment partners in Durham, NC, gave a talk on the prevention of lead exposure in Durham’s communities. CHHE’s Community Outreach and Engagement Core works closely with community groups in Durham to address and reduce toxic metal exposure, making Lorisa’s talk especially relevant. Dr. Michael Waalkes, former Chief of the NCI/NIEHS’s Inorganic Carcinogenesis Section and a pioneer in the field of metal toxicology and carcinogenesis, delivered the keynote address highlighting his seminal discoveries in metals and carcinogenesis over his 33-year career in public service.

The remainder of the day was filled with presentations by CHHE members highlighting their research expertise and scientific discovery in the area of toxic metals involving ecotoxicology, environmental remediation, exposure science, susceptibility, model systems, genetics and epidemiology.  CHHE members and their postdocs and graduate students shared their science during two poster sessions.

See NIEHS article on CHHE symposium.

Special Thanks to CHHE Events Committee
A special thank you to David Aylor, Mike Cowley, John House, Katy May, Matt Polizzotto, and Jung-Ying Tzeng for the fantastic job they did in organizing the first CHHE Symposium.  The meeting was a huge success and the bar has been set high for next year’s symposium!  Thanks to Jackie Broughton for coordinating and managing all the pieces.

Funding Opportunities 

The NC State University Center for Human Heath and the Environment (CHHE) is announcing its request for applications (RFA) for pilot project proposals for Spring 2017.  Applications will be due on April 3, 2017.

The NC State University Center for Human Heath and the Environment (CHHE) is announcing a new request for applications (RFA) for pilot project proposals for Spring 2017. The overarching objective of the Center for Human Health and the Environment’s Pilot Project Program (PPP) is to expand environmental health science research at NC State, ECU and NCCU.  Pilot project funding to Center members and other NC State, ECU and NCCU investigators is awarded to collect preliminary data that will support applications for external funding from the National Institute of Environmental Health Sciences (NIEHS), other NIH Institutes and Federal agencies. Consequently, the major emphasis of the PPP is on research into the effects, potential consequences and prevention of environmental exposures on human health. The PPP will support high quality basic, applied, clinical and public health research.  The PPP will provide funding for individual, collaborative and multidisciplinary research aimed at understanding the adverse impacts of environmental factors on human health and disease. Multidisciplinary collaborations and use of CHHE’s core facilities are strongly encouraged but not required.  CHHE anticipates funding up to 5-6 awards for this round. Abstract pre-submission ( is encouraged but not required to determine if proposal topics are consistent with the mission of the CHHE. Individual awards will range up to $25,000 direct costs for one year. Applications will be due on April 3, 2017.  Application and additional information can be found at and questions can be directed to Jamie Bonner (, Director of CHHE PPP.

CHHE and the Toxicology Program Joint Seminar: Humphrey Yao, NIEHS "Sex, Arsenic, and Hedgehog: Mouse Models of Fetal Origins of Adult Diseases". Tuesday, March 21, 2017 at 4:00 pm, Toxicology Building Auditorium Rm 2104.
Dr. Humphrey Hung-Chang Yao leads the Developmental Reproductive Biology Group in the Laboratory of Reproductive and Developmental Toxicology at NIEHS/NIH at Research Triangle Park in North Carolina. Dr. Yao received his doctoral degree at the University of Illinois in Urbana-Champaign in 1999 and then completed his postdoctoral training at Duke University Medical Center in 2002. He became Assistant Professor in the Department of Comparative Biosciences at University of Illinois in Urbana-Champaign in 2003 and received tenure in 2009. Dr. Yao is the recipient of the Basal O'Connor Starter Research Award from March of Dimes Birth Defect Foundation, Pfizer Research Award, New Investigator Award for the Society for the Study of Reproduction, and Young Andrologist Award from the American Society of Andrology. His Group is using organogenesis of the gonads and reproductive tracts as the model to understand the basic process of organ formation as well as the potential implication on impacts of endocrine disruptor exposure on reproductive system development in fetuses and fertility in adulthood.
The Brody School of Medicine, Department of Public Health at East Carolina University will be hosting, "Climate Change and Health: Focus on Eastern N.C." at the East Carolina Heart Institute on Thursday, March 23, 2017 at 9:00 am - 3:00 pm in Greenville
The purpose of the event is to raise awareness of climate change and health impacts on eastern North Carolina. The symposium aims to stimulate synergy and increase communication surrounding this issue among researchers, healthcare professionals, faculty, students and local community.  Faculty, students and researchers outside of ECU are welcome to attend.   
Invited speakers include representatives from the Centers for Disease Control and Prevention (CDC), US EPA, NC DHHS, Division of Public Health, Carolinas Health Care System, and The Southeast Regional Climate Center. The event is being co-sponsored by the gracious support of Clean Air Carolina, and NCSU Center for Human Health and the Environment (CHHE).  Lunch will be provided and pre-registration is required. Participants interested in presenting a poster are invited to submit an abstract through the registration website.
To register for the symposium, please visit, For more information, please contact Dr. Greg Kearney at ECU, Department of Public Health, at (252) 744-4039 or via email at

Associate Membership Available for Post-doctoral fellows: Postdocs and Research Associates with interests in Environmental Health Science can apply for Associate Membership in the Center. Prospective new members may self-nominate or be nominated by a CHHE member. The criteria for Associate Membership in the Center are: 1) Postdoc or Research Associate status at one of the CHHE partners; 2) significant interest in environmental health science; and 3) relevance of the individual’s research program to environmental health science.


Hong Wang and her colleagues Drs. Lim and Riehn received a new NIEHS R21 entitled “Rotational Tracking of Single Nanoplasmonic Upconverting Nanoparticle-Conjugated Proteins on DNA.” The overall goal of this project is to apply new protein labeling strategies to better understand the curvilinear motion of protein-DNA interactions during encountering of DNA lesions.
Congratulations to Hong Wang for her new paper “Nucleosome-like, ssDNA-histone octamer complexes and the implication for DNA double-strand break repair” in Journal of Biological Chemistry.  It will be in the April 2017 issue.
Thanks to Hong for remembering to cite CHHE in the acknowledgements!  Please remember to cite the CHHE grant in all your papers that CHHE helped make happen.  It helps us demonstrate the impact of the center.  Here’s the citation information: Research reported in this publication was supported in part by NIEHS under award number P30ES025128
Congratulations to COEC director Katy May for having her symposium selected for the International Society of Exposure Science meeting in RTP, NC in October 2017. CHHE members Chris Frey, Aaron Hipp, Carolyn Mattingly, and David Reif were part of other successful symposium submissions.  Jane Hoppin is one of the co-chairs.  Abstract submissions are now open. For more information on this meeting, please go to

COEC Update

The COEC is hard at work with other CHHE members, Cathrine Hoyo and Matt Polizzotto, to submit a Research-to-Action proposal to NIEHS. The proposal is for a community-based participatory research project in Durham, building on previous heavy metal data and community partnerships established over the last few years. This grant is unique in that in emphasizes community involvement and ownership throughout the research, dissemination, and intervention processes. 

Interested in having your research take a more community-based approach? Email to find out how! 


PINS: Remember when submitting your grants, be sure to select "Center for Human Health and the Environment" as a center in PINS.

Acknowledgements: Remember to cite our CHHE grant P30ES025128 in publications if CHHE has provided you services, facility core use, seed/pilot project funds etc. NIH tracks this as an important CHHE metric.

CHHE Logo: Please use the CHHE logo in your presentations. You can find it on the

CHHE Resources and Facilities Page for NIH Grants is now available on the CHHE


Humphrey Hung-Chang Yao, NIEHS
"Sex, Arsenic, and Hedgehog: Mouse Models of Fetal Origins of Adult Diseases”
March 21, 2017 Toxicology Building Auditorium 4:00 pm - 5:00 pm

Rick Woychik, NIEHS
"Research Strategies for Exploring the Landscape of Environmental Health"
April 25, 2017 Toxicology Building Auditorium 4:00 pm - 5:00 pm

CHHE Calendar of events

CHHE Member Resources 
CHHE offers a host of resources for Center members: seed money for use in Facility Cores, Facility Cores for Pathology, Proteomics, Genomics, and Metabolomics, bioinformatic support, career development opportunities, travel funds, and more.  Check out the website for more details.  And, remember, if you take advantage of these resources be sure to cite the Center (P30ES025128) in the acknowledgments of papers.

Research Money for CHHE members: CHHE Seed Funds
CHHE is providing up to $5000/year to each CHHE member to defray the cost associated with using the Comparative Pathology Core (immunohistochemical staining , tissue embedding and processing, etc.) or the Systems Technologies Core, including the Genomics (RNAseq etc), Proteomics (targeted and discovery proteomics), and Metabolomics sections (analysis of endorgenous and exogenous compounds; metals, xenobiotics etc) for environmental health science related projects. CHHE will also consider providing funds to support EHS research associated with the Integrative Health Sciences Facility and Community Outreach and Engagement Cores. For more details, click on 

CHHE 2016 Travel/Workshop Award Announcement - - Rolling deadline
One of CHHE's missions is to support career development of new and early stage investigators. As part of the effort, CHHE will provide awards (up to $1,000) to help defray the cost of travel to scientific meetings or small symposia relevant to environmental health science or a workshop that will provide new skills. Travel/Workshop awards will be reviewed and prioritized by members of the 
Career Development Core. Your request should be succinct (less than 250 words) and document the importance of attending the requested meeting/workshop. Please aldo include the entire budget for travel/registration, etc. Please send your proposals to Jackie Broughton.

**See the for more information**

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Center for Human Health and the Environment · NC State University · Campus Box 7633 · Raleigh, NC 27607 · USA

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