Core Updates 
The Comparative Pathology Core  which provides pathology training, laser capture microdissection and pathology assessment of a diverse range of animal models and Systems Technologies Core which provides genomic, metabolic, and proteomic analyses are open for service, consultation and collaboration with CHHE members. Dedicated bioinformatic support is also available. 
Integrative Health Science Facility Core can help you translate your findings from animal/cell models to humans or vice versa.  This core can help you procure human tissues/specimans, help with conduct of human studies (questionnaire development, IRB assistance), use of the comparative toxicogenomic database (CTD, either with specialized training or data curation, assess to clinical populations at ECU, and much more.
Community Outreach and Engagement Core (COEC) to help extend the reach of our research to communities in NC and beyond.
**See the for more information**

CHHEK Updates
Where do the CHHE members                                             What model systems do CHHE                      come from?                                                                             members use?                                                                                   
CHHEK Survey             
Please complete your CHHEK survey at the link below:

This Issue's Core Highlight

The Career Development Core 
Do you want help writing grants?  Whether you are a seasoned investigator or a new environmental health science researcher, the Career Development Core has something for you.  For people who want help all the way through the grant development and writing process, the Career Development Core has a mentoring program to help you be successful navigating the process.  Starting in August, the Career Development Core Faculty will meet regularly to discuss, evaluate and refine the CHHE mentoring and grant writing programs.
We are also hosting a series of seminars that will be of interest to investigators at all career stages. 

New NIH Biosketch Workshop.  August 17, 2015. This workshop will help you create the new biosketch required for NIH grants.  More details at the bottom of the newsletter.

Constructing Effective Specific Aims. September 2015.  This workshop will focus on how to construct effective Specific Aims, again directed at improving NIH proposals.  [More details to come – check your email]

Contact Chris McGahan if you would like help with an upcoming grant submission.  For more information on the Career Development Core, see the CHHE website.
Welcome New Members!!
Jodie Fleming - Dept. of Biology, NCCU
Sophia Kathariou - Dept. of Food, Bioprocessing & Nutrition Sciences, NCSU
William Meggs - Dept. of Emergency Medicine, ECU
Xiaoping Pan - Dept. of Biology, ECU


PINS: Remember when submitting your grants, be sure to select CHHE as a center in PINS.

Research Teams are starting to meet to discuss topics they'd like to work on together and what types of events/enrichment activities they'd like CHHE to offer.

Acknowledgements: Please remember to cite our CHHE P30 grant ES025128 in publications if CHHE has provided you services, facility core use, seed/pilot project funds etc. NIH tracks this and this is an important CHHE metric.

Seminars: We will be updating the CHHE calendar with seminars and events. Please send Jackie seminar announcements/events etc. to include these in the CHHE calendar.

Coming this fall: Claudia Thompson, PhD., NIEHS Program Officer to talk about Environmental Health Science grant opportunities.
CHHE Website
CHHE website is currently being updated!  We're adding all team members to the research team pages - check out your Photo and short research bio!  If you prefer a different photo, please send to Jackie Broughton to replace.  

David Reif served as a member of the IARC Working Group that drew experts from 13 countries to a meeting in Lyon, France in June. The Group evaluate the carcinogenicity of the the insecticides gamma-hexachlorocyclohexane (lindane) and dichlorodiphenyltrichloroethane (DDT) and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D).  Summaries of the final evaluations are available in the official press release and Lancet Oncology article. The detailed assessments will be published as Volume 113 of the IARC Monographs.  

Jamie Bonner served as an ad hoc member of the NIH study section, Systemic Injury by Environment Exposure (SIEE) in June. SIEE reviews applications related to the pharmacological and toxicological mechanisms of adverse outcomes that can occur in individuals and populations exposed to xenobiotics 

Michael Bereman, Leader of the CHHE Proteomics Group was awarded in June a prestigious American Society of Mass Spectrometry Research Award. This award is bestowed upon early-stage faculty members to promote academic research in mass spectrometry.

Coby Schal, professor in entomology, was the invited expert in the News and Observer, Ask a Scientist column.  He answered questions on cockroaches.  For more information see:

Jun Ninomiya-Tsuji received an R01 from National Institute of General Medicine for her project:  TAK1 regulation of metabolism.

           **Please be sure to send us your "kudos" for our next newsletter**
Send us information on recent grants you have received (title, agency, amount) so we can include it in our next newsletter!

Upcoming Events
 Special CHHE workshop on the new NIH/NSF biosketch: August 17th, 12:00PM - 2:00PM.  
Toxicology Auditorium,  Rm 2104
**Please bring a laptop that contains your biosketch**
Visit link below to register
CHHE will host seminar speakers in the fall and spring.  Check them out on the calendar

CHHE Publications
  Maternal cadmium, iron and zinc levels, DNA methylation and birth weight.
  Vidal AC, Semenova V, Darrah T, Vengosh A, Huang Z, King K, Nye MD, Fry R, Skaar D, Maguire R, Murtha A, Schildkraut J, Murphy S, Hoyo C.
  BMC Pharmacol Toxicol. 2015 Jul 15;16(1):20. doi: 10.1186/s40360-015-0020-2.
  PMID: 26173596 [PubMed - in process] Free PMC Article
  Suboptimal nutrient balancing despite dietary choice in glucose-averse German cockroaches, Blattella germanica.
  Jensen K, Schal C, Silverman J.
  J Insect Physiol. 2015 Jul 2;81:42-47. doi: 10.1016/j.jinsphys.2015.07.001. [Epub ahead of print]
  PMID: 26145203 [PubMed - as supplied by publisher]
  High-throughput characterization of chemical-associated embryonic behavioral changes predicts teratogenic outcomes.
  Reif DM, Truong L, Mandrell D, Marvel S, Zhang G, Tanguay RL.
  Arch Toxicol. 2015 Jul 1. [Epub ahead of print]
  PMID: 26126630 [PubMed - as supplied by publisher]
  Genetic architecture of natural variation in Drosophila melanogaster aggressive behavior.
  Shorter J, Couch C, Huang W, Carbone MA, Peiffer J, Anholt RR, Mackay TF.
  Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3555-63. doi: 10.1073/pnas.1510104112. Epub 2015 Jun 22.
  PMID: 26100892 [PubMed - in process] Free PMC Article
  Hypothesis testing at the extremes: fast and robust association for high-throughput data.
  Zhou YH, Wright FA.
  Biostatistics. 2015 Jul;16(3):611-25. doi: 10.1093/biostatistics/kxv007. Epub 2015 Mar 18.
  PMID: 25792622 [PubMed - in process]
Impact of Low Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study.   
  Rebuli ME, Camacho L, Adonay ME, Reif DM, Aylor D, Patisaul HB.
  Toxicol Sci. 2015 Jul 23. pii: kfv163. [Epub ahead of print]
  PMID: 26209558 [PubMed - as supplied by publisher]

Comparative oncology: what dogs and other species can teach us about humans with cancer
By: Schiffman, Joshua D.; Breen, Matthew
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES Volume: 370   Issue: 1673     Article Number: UNSP 20140231  Published: 
JUL 19 201

Peto's paradox and the promise of comparative oncology.
By: Nunney, Leonard; Maley, Carlo C; Breen, Matthew; et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences Volume: 370   Issue: 1673     Published: 2015-Jul-19

Associations between prenatal physical activity, birth weight, and DNA methylation at genomically imprinted domains in a multiethnic newborn cohort
By: McCullough, Lauren E.; Mendez, Michelle A.; Miller, Erline E.; et al.
EPIGENETICS Volume: 10   Issue: 7   Pages: 597-606   Published: JUL 3 2015

Assessment of critical exposure and outcome windows in time-to-event analysis with application to air pollution and preterm birth study
By: Chang, Howard H.; Warren, Joshua L.; Darrow, Lnydsey A.; et al.
BIOSTATISTICS Volume: 16   Issue: 3   Pages: 509-521   Published: JUL 2015

Accuracy of SNPs to predict risk of HLA alleles associated with drug-induced hypersensitivity events across racial groups.
By: He, Yijing; Hoskins, Janelle M; Clark, Scott; et al.
Pharmacogenomics Volume: 16   Issue: 8   Pages: 817-24   Published: 2015-Jul (Epub 2015 Jun 17)
By: Gruen, Margaret E.; Case, Beth C.; Foster, Melanie L.; et al.
By: Poteat, Monica D.; Jacobus, Luke M.; Buchwalter, David B.
FRESHWATER BIOLOGY Volume: 60   Issue: 7   Pages: 1330-1339   Published: JUL 2015
The residual risk of transfusion-transmitted cytomegalovirus infection associated with leucodepleted blood components
By: Seed, C. R.; Wong, J.; Polizzotto, M. N.; et al.
VOX SANGUINIS Volume: 109   Issue: 1   Pages: 11-17   Published: JUL 2015

Epigenetic regulation of Newborns' imprinted genes related to gestational growth: patterning by parental race/ethnicity and maternal socioeconomic status
By: King, Katherine; Murphy, Susan; Hoyo, Cathrine
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH Volume: 69   Issue: 7   Pages: 639-647   Published: JUL 2015

Incidence of solid tumours among pesticide applicators exposed to the organophosphate insecticide diazinon in the Agricultural Health Study: an updated analysis
By: Jones, Rena R.; Barone-Adesi, Francesco; Koutros, Stella; et al.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE Volume: 72   Issue: 7   Pages: 496-503   Published: JUL 2015
By: Kearney, Gregory D; Rodriguez, Guadalupe; Quandt, Sara A; et al.
American journal of public health Volume: 105   Issue: 7   Pages: 1336-43   Published: 2015-Jul (Epub 2015 May 14)
By: Zhang, Wenwen; Vinueza, Nelson R.; Datta, Preeta; et al.
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY Volume: 53   Issue: 13   Pages: 1594-1599   Published: JUL 1 2015