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Vol. 1 No.9 March 2016
Upcoming Events

March 10, 2016 Pilot Project Proposals Due
Details located here

March 15, 2016 Anthony Ingraffea, Cornell
"The Science of Shale Gas/Oil: The Latest Evidence on Leaky Wells and Methane Emissions, and Implications for Energy Policy"
2:30 pm James B. Hunt Library, Duke Energy Hall - room D
 
April 8, 2016 CHHE Retreat: Save the Date
12:00-6:00 JC Raulston Arboretum
RSVP to
Jackie Broughton

April 19, 2016 Dana Dolinoy, University of Michigan
"Perinatal Environmental Exposures: Effects on Metabolic Homeostasis and the Epigenome"
4:00 pm Toxicology Building Auditorium

Announcements
 
March 15, 2016 Anthony Ingraffea: Special Seminar
"The Science of Shale Gas/Oil: The Latest Evidence on Leaky Wells and Methane Emissions, and Implications for Energy Policy"
CHHE is honored to work with Clean Water Action and the Frackfree NC alliance to host Dr. Antony Ingraffea for a special seminar on March 15 at 2:30 in the James B. Hunt Library, Duke Energy Hall - room D. Dr. Ingraffea is a world expert on hydraulic fracturing for natural gas development.  He was recognized by TIME Magazine in 2011 as one of it's "People Who Mattered".  Please join us for this interesting talk.  Please encourage your students to attend as well.

April 8, 2016 CHHE Retreat
Come join us for the 2nd CHHE retreat on April 8, 2016 at the Arboretum (directions, 12-6 pm).  Join your fellow CHHE members for lunch and updates about the Center's activities.  Learn about the activities of the Community Outreach and Engagement Core.  Hear updates from the pilot projects.  Connect with others about potential future research in environmental health sciences.  Bring your walking shoes.  If it's a nice day, we promise to get you outside!  RSVP to Jackie Broughton.

CHHEK Knowledge Database
Want to find out what other people are doing in the Center? Want to find a piece of equipment or software?  Well, look no further, the CHHE Knowledge Database (CHHEK) is up and running. You can use CHHEK to find out other members research interests, equipment availability, and much much more. Go check out your profile to make sure your information is complete.  If not, you can input any missing data by filling out that portion of the survey. Thanks to Carolyn Mattingly and Galen Collier for making this happen!

Event of Interest: NIH Transgenerational Workshop - April 21-22, 2016
https://tools.niehs.nih.gov/conference/transgenerational_2016/

Volunteers Needed: CHHE is looking for volunteers for our newly formed Events Committee.  This committee will help organize a cross-cutting workshop or symposium annually.  We would like to have members from each of the research teams.  Contact your team leader if you are interested in this exciting opportunity.

Welcome New Members

Belinda Akpa, Assistant Professor, Dept. of Molcular Biomedical Sciences, CVM
Ernest Hodgson, Distinguished Professor Emeritus, Dept. of Applied Ecology, CALS
John House, Research Scholar, Bioinformatics Research Center, COS
Dereje Jima, Research Scholar, Center for Human Health and the Environment, ORIED
Jennifer Runkle, Research Scholar, NC Institute of Climate Studies

Kudos & News!
 
Jamie DeWitt, ECU, will be running a workshop  “Water Toxicology Workshop” for students attending the NC Youth Ocean Conservation Summit at the Pine Knoll Shores Aquarium this Saturday (2/27/16 -https://sites.google.com/a/ncsu.edu/nc-youth-ocean-conservation-summit/home/skill-building-workshop-leaders). She’ll be talking specifically about water quality in eastern NC and the importance of estuaries in “decontaminating” water. There will be about 70 students attending this event.
 
Kym Gowdy, ECU, is being awarded the  Outstanding Young Investigator award from the Immunotoxicology Specialty Section Award at the SOT meeting this year. 

COEC Update

Community Outreach and Engagement Core
 
This month the COEC held two focus groups to discuss with fishing communities how to improve the communication of North Carolina (AMEXCAN), a community-based outreach organization for Mexicans and Latinos/as in eastern North Carolina.  A second focus group was held on February 22 with African American fishermen in Moncure.  Focus groups findings will help us to craft messages that weigh the risks and benefits of fish consumption and alert fishers to statewide and site-specific advisories.

The COEC continues to make progress on developing its online presence, putting some of the final touches on its social media platforms and website content. Stay tuned for the official launch next month!

Funding Opportunities 
 
Acknowledgements: Remember to cite our CHHE grant P30ES025128 in publications if CHHE has provided services, facility core use, seed/pilot project funds etc. NIH tracks this as an important CHHE metric. "Research reported in this publication was supported NIEHS under award number P30ES025128 Center for Human Health and the Environment.".

2016 Pilot Project Call  
All CHHE members as well as NC State, East Carolina University, and NCCU faculty are eligible for these one year up to $25,000 direct research grants.  Due March 10, 2016.  Please visit the 
website for more details and to obtain 2016 CHHE Pilot Project instructions. Remember you can consult with the CHHE bioinformatician Dereje Jima for help with study design. 

Metabolomics RFA from RTI: Due March 15 - up to $50,000 for metabolomic services at RTI
http://www.rti.org/files/NIHRCMRCcallforapplications.pdf

Duke and NC State Collaborate on Translational Research Grant
Applications are now being accepted for projects that involve a lead investigator from Duke and a lead investigator from NC State. Proposals are encouraged from new teams of investigators representing two or more distinct disciplines. Up to two awards may be funded this cycle.  The 2016-2017 grant will fund up to $25,000 per institution for a total of $50,000 per funded project. The deadline for application submission is April 1, 2016.
 For more information, read the RFA here.

NC State Office of Research, Innovation, and Economic Development has announced a new program GRIP (Game-Changing Research Incentive Program).  Pre-proposals due May 31, 2016
GRIP will allocate more than $1,500,000 over three years to fund exceptional research teams and projects that span NC State colleges. GRIP is intended to incentivize and support visionary research ideas that will result in large-scale extramural funding, award-winning research impacts, and first-class interdisciplinary graduate education and training. For more information about GRIP (including a copy of the RFP and a short video about the program) please visit https://research.ncsu.edu/rdo/funding/internal-funding/grip/.

There is a webinar about this scheduled for March 3rd from 12 - 1 pm.  Feel free to join us in the CHHE conference room to watch.
 
Integrating Human Health and Well-Being with Ecosystem Services 
URL: 
http://www.epa.gov/research-grants/integrating-human-health-and-well-being-ecosystem-services 

Open Date: 02/22/2016 - Close Date: 04/21/2016 
The U.S. Environmental Protection Agency (EPA) announces the release of the Integrating Human Health and Well-Being with Ecosystem Services Request for Applications.  This RFA goal is to fund community-based research that will foster better understanding of how human health and well-being are interconnected with—and depend on—ecosystem services. Specifically, this research examines how communities can integrate ecosystem services with human health and well-being to inform their decision making and management practices. This RFA aims to develop information that allows communities to integrate environmental, societal and economic information and to better manage multiple stressors and their cumulative impacts on humans and ecosystems. The ultimate goal is to help communities achieve their own objectives while taking advantage of more relevant and accessible information about ecosystem services. The Integrating Human Health and Well-Being with Ecosystems Services RFA is part pf EPA’s Sustainable and Healthy Communities (SHC) Research program. The SHC Research Program provides useful science and tools for decision makers at all levels to help communities advance sustainability as well as achieve regulatory compliance.  SHC is collaborating with partners to conduct research that will result in science-based knowledge to guide decisions that will better sustain a healthy society and environment in America's communities. Partnerships and community engagement are strongly encouraged for this research.

Reminders

PINS: Remember when submitting your grants, be sure to select "Center for Human Health and the Environment" as a center in PINS.

Research Teams are meeting to discuss topics to work on together and what types of events/enrichment activities they would like CHHE to offer.

Acknowledgements: Remember to cite our CHHE grant P30ES025128 in publications if CHHE has provided you services, facility core use, seed/pilot project funds etc. NIH tracks this as an important CHHE metric.

CHHE Logo: Please use the CHHE logo in your presentations. You can find it on the
website 

CHHE Resources and Facilities Page for NIH Grants is now available on the CHHE
website.

Seminars

Upcoming CHHE Seminars:

Anthony Ingraffea - Cornell University
"The Science of Shale Gas/Oil: The Latest Evidence on Leaky Wells and Methane Emissions, and Implications for Energy Policy" March 15, 2016 2:30 pm - James B. Hunt Library, Duke Energy Hall, room D.

Dana Dolinoy - University of Michigan - "Perinatal Environmental Exposures: Effects on Metabolic Homeostasis and the Epigenome". April 19, 2016  4:00 pm - Toxicology Building Auditorium.
 
Seminars: Send Jackie seminar announcements/events etc. for the CHHE calendar.

CHHE Member Resources 
 
The CHHE has cores for members to use to enhance their research. Seed money is available to members to spend in the cores.  These cores are:

The Comparative Pathology Core  provides pathology training, laser capture microdissection and pathology assessment of a diverse range of model organisms as well consultation
and opportunities for collaboration.


The Integrative Health Science Facility Core can help you translate your findings from animal/cell models to humans or vice versa.  This core can help you obtain human tissues/specimens, help with conduct of human studies (questionnaire development, IRB assistance), use of the comparative toxicogenomic database (CTD, ctdbase.org) either with specialized training or data curation, access to clinical populations at ECU, and much more.

The Systems Technologies Core provides genomic, metabolomics and proteomic analysis as well as consultation and opportunities for collaboration.

Dedicated Bioinformatic support is available for CHHE members.

Career Development Core provides grant writing help to early stage investigators and those new to environmental health sciences research. This core also provides funding for early stage investigators to attend a scientific meeting/workshop. 

 
Community Outreach and Engagement Core (COEC) extends the reach of our research to communities in NC and beyond. The COEC can help you translate your research findings for the general public.

Research Money for CHHE members: CHHE Seed Funds
CHE is providing up to $3000/year to each CHHE member to defray the cost associated with using the Comparative Pathology Core (immunohistochemical staining , tissue embedding and processing, etc.) or the Systems Technologies Core, including the Genomics (RNAseq etc), Proteomics (targeted and discovery proteomics), and Metabolomics sections (analysis of endorgenous and exogenous compounds; metals, xenobiotics etc) for environmental health science related projects. CHHE will also consider providing funds to support EHS research associated with the Integrative Health Sciences Facility and Community Outreach and Engagement Cores. For more details, click on 
link.

CHHE 2016 Travel/Workshop Award Announcement - - Rolling deadline
One of CHHE's missions is to support career development of new and early stage investigators. As part of the effort, CHHE will provide awards (up to $1,000) to help defray the cost of travel to scientific meetings or small symposia relevant to environmental health science or a workshop that will provide new skills. Travel/Workshop awards will be reviewed and prioritized by members of the 
Career Development Core. Your request should be succinct (less than 250 words) and document the importance of attending the requested meeting/workshop. Please aldo include the entire budget for travel/registration, etc. Please send your proposals to Jackie Broughton.


 
**See the http://chhe.research.ncsu.edu/ for more information**

CHHE Publications
 
Natural variability in Drosophila larval and pupal NaCl tolerance.
Riedl CA, Oster S, Busto M, Mackay TF, Sokolowski MB.
J Insect Physiol. 2016 Feb 10;88:15-23. doi: 10.1016/j.jinsphys.2016.02.007. [Epub ahead of print] PMID:26874056
 

Factors Influencing Dislodgeable 2, 4-D Plant Residues from Hybrid Bermudagrass (Cynodon dactylon L. x C. transvaalensis) Athletic Fields.
Jeffries MD, Gannon TW, Brosnan JT, Ahmed KA, Breeden GK.
PLoS One. 2016 Feb 10;11(2):e0148992. doi: 10.1371/journal.pone.0148992. eCollection 2016. PMID:26863005
 

The Genetic Basis for Variation in Sensitivity to Lead Toxicity in Drosophila melanogaster.
Zhou S, Morozova TV, Hussain YN, Luoma SE, McCoy L, Yamamoto A, Mackay TF, Anholt RR. Environ Health Perspect. 2016 Feb 9. [Epub ahead of print] PMID:26859824
 

Frogs as integrative models for understanding digestive organ development and evolution.
Womble M, Pickett M, Nascone-Yoder N.
Semin Cell Dev Biol. 2016 Feb 3. pii: S1084-9521(16)30046-5. doi: 10.1016/j.semcdb.2016.02.001. [Epub ahead of print] Review. PMID:26851628
 

Climate Justice in Rural Southeastern United States: A Review of Climate Change Impacts and Effects on Human Health.
Gutierrez KS, LePrevost CE.
Int J Environ Res Public Health. 2016 Feb 3;13(2). pii: E189. doi: 10.3390/ijerph13020189. Review. PMID:26848673
 

Fresh Produce-Associated Listeriosis Outbreaks, Sources of Concern, Teachable Moments, and Insights.
Garner D, Kathariou S.
J Food Prot. 2016 Feb;79(2):337-44. doi: 10.4315/0362-028X.JFP-15-387.
PMID:26818997
 

Comparative sodium transport patterns provide clues for understanding salinity and metal responses in aquatic insects.
Scheibener SA, Richardi VS, Buchwalter DB.
Aquat Toxicol. 2016 Feb;171:20-9. doi: 10.1016/j.aquatox.2015.12.006. Epub 2015 Dec 17. PMID:26730725


Epistatic partners of neurogenic genes modulate Drosophila olfactory behavior.
He X, Zhou S, St Armour GE, Mackay TF, Anholt RR.
Genes Brain Behav. 2016 Feb;15(2):280-90. doi: 10.1111/gbb.12279. Epub 2016 Jan 18. PMID:26678546
 

Protozoal nodular dermatitis and panniculitis in a Rottweiler puppy caused by Caryospora bigenetica.
Tham HL, Linder KE, Tucker A, Maggi R, Bizikova P.
Vet Dermatol. 2016 Feb;27(1):44-e12. doi: 10.1111/vde.12271. Epub 2015 Nov 15. PMID:26567903
 

Regulatory links between imprinted genes: evolutionary predictions and consequences
By: Patten, Manus M.; Cowley, Michael; Oakey, Rebecca J.; et al.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES  Volume: 283 Issue: 1824 Pages: 52760-52760 Published: FEB 10 2016
 

Perspectives from man's best friend: National Academy of Medicine's Workshop on Comparative Oncology
By: LeBlanc, Amy K.; Breen, Matthew; Choyke, Peter; et al.
SCIENCE TRANSLATIONAL MEDICINE  Volume: 8  Issue: 324  Article Number: 324ps5  Published: FEB 3 2016
 

Validation of a Metallomics Analysis of Placenta Tissue by Inductively-Coupled Plasma Mass Spectrometry
By: Harrington, James M.; Young, Daniel J.; Fry, Rebecca C.; Sumner, Susan; et al.
BIOLOGICAL TRACE ELEMENT RESEARCH  Volume: 169 Issue: 2 Pages: 164-173 Published: FEB 2016
 

PHARMACOMETABOLOMICS SIGNATURES FROM WOMEN WITH PREMENSTRUAL DYSPHORIC DISORDER ADMINISTERED ESTRADIOL AND PROGESTERONE TREATMENT.
By: Rotroff, D.; Gaikwad, N. W.; Reuter, J. M.; Motsinger-Reif, Alison A.; et al.
Conference: Annual Meeting of the American-Society-for-Clinical-Pharmacology-and-Therapeutics (ASCPT) Location:San Diego, CA Date: MAR 08-12, 2016 
Sponsor(s): Amer Soc Clin Pharmacol & Therapeut CLINICAL PHARMACOLOGY & THERAPEUTICS  Volume: 99 Supplement: 1 Pages: S19-S19 Meeting Abstract:PT-22 Published: FEB 2016
 

PHARMACOMETABOLOMIC SIGNATURES OF SUBJECTS WITH REFRACTORY MAJOR DEPRESSIVE DISORDER TREATED WITH ESKETAMINE OR KETAMINE
By: Rotroff, D. M.; Corum, D. G.; Motsinger-Reif, A. A.; et al.
Conference: Annual Meeting of the American-Society-for-Clinical-Pharmacology-and-Therapeutics (ASCPT) Location:San Diego, CA Date: MAR 08-12, 2016 
Sponsor(s): Amer Soc Clin Pharmacol & Therapeut CLINICAL PHARMACOLOGY & THERAPEUTICS  Volume: 99 Supplement: 1 Pages: S27-S28 Meeting Abstract:E-029 Published: FEB 2016
 

California forests show early indications of both range shifts and local persistence under climate change
By: Serra-Diaz, Josep M.; Franklin, Janet; Dillon, Whalen W.; Meentemeyer, Ross K.; et al.
GLOBAL ECOLOGY AND BIOGEOGRAPHY  Volume: 25 Issue: 2 Pages: 164-175 Published: FEB 2016


Expression of WNT5A in Idiopathic Pulmonary Fibrosis and Its Control by TGF-beta and WNT7B in Human Lung Fibroblasts.
By: Newman, Donna R; Sills, W Shane; Hanrahan, Katherine; Sannes, Philip; et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society  Volume: 64 Issue: 2 Pages: 99-111 Published: 2016-Feb (Epub 2015 Nov 04)
  

Protozoal nodular dermatitis and panniculitis in a Rottweiler puppy caused by Caryospora bigenetica
By: Tham, Heng L.; Linder, Keith E.; Tucker, Alison; et al.
VETERINARY DERMATOLOGY  Volume: 27 Issue: 1 Pages: 44-E12 Published: FEB 2016
 

Interaction models for functional regression
By: Usset, Joseph; Staicu, Ana-Maria; Maity, Arnab
COMPUTATIONAL STATISTICS & DATA ANALYSIS  Volume: 94 Pages: 317-329 Published: FEB 2016