PhD thesis defense in Biological sciences: "Trypanosoma brucei"
UNamur, M01 auditorium
Arnaud Machelart will present his PhD thesis entitled "Impact de l'asthme allergique et de l'infection par Trypanosoma brucei sur le contrôle de l’infection par Brucella melitensis chez la souris" (promoter: Prof. Jean-Jacques Letesson)
MIDI PUNCH: "Les étudiants-chercheurs, une autre façon d’apprendre"
UNamur, Salle académique de la Faculté d’informatique
This meeting will address the educational initiatives allowing students to gain a real experience in scientific research. Prof. Stéphane Lucas (Department of Physics, UNamur) and Prof. Jean-Michel Vandeweerd (Department of Veterinary Medicine, UNamur) will present how NARILIS encourages since 2010 bachelor students to perform mini-research projects and what are the benefits and challenges of these initiatives.
More than 80 scientists and clinicians gathered at the UNamur on the 17th of November 2016
Prof. Martine Raes, Vice-rector for Research of UNamur, and Prof. Jean-Christophe Renauld, Pro-rector for Research of UCL, were side-by-side to support NARILIS institute and to encourage multidisciplinary and collaborative research!
Furthermore, NARILIS key research areas were brilliantly showcased by pairs of Principal Investigators and young researchers.
See the presentations of the NARILIS Research Day:
Increased risk of vascular occlusive events with new generation BCR-ABL tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia - Updated meta-analysis
In a previous meta-analysis, the NTHC highlighted that new generation tyrosine kinase inhibitors (TKIs), such as ponatinib, nilotinib and dasatinib, increase the risk of vascular occlusive events, compared to imatinib, the first TKI approved for the treatment of patients with chronic myeloid leukemia (Douxfils et al., 2016). More recently, a new meta-analysis of randomized controlled trials was performed to separately assess the risks of arterial and venous occlusive events. This new study indicates that vascular occlusive events associated with new generation BCR-ABL TKIs are mainly driven by arterial occlusive events.
Impact of direct oral anticoagulants (DOACs) on activated clotting time Atrial fibrillation (AF) is the most common type of arrhythmia. Catheter ablation is an invasive procedure used to treat AF, but which is associated with a significant risk of thrombotic events. Concomitant administration of unfractionated heparin and monitoring of the intraprocedural anticoagulation intensity using activated clotting time (ACT) is highly recommanded for lowering the complications.
Catheter ablation can be performed safely without interruption of DOACs therapy. However, little is known about the interference of these drugs with the ACT. Therefore, the NTHC performed an in vitro study by spiking blood samples collected from one healthy donor with 4 licensed DOACs, followed by ACT measurement. This preliminary work showed that dabigatran interferes more than anti-Xa agents (rivaroxaban, apixaban and edoxaban) on the ACT.
In vitro modeling of atopic dermatitis using reconstructed human epidermis
Atopic dermatitis is a chronic inflammatory skin disease, in which IL-4, IL-13 and IL-25, Th2 pro-inflammatory cytokines, are known to be key drivers of the underlying inflammatory process. The Cell and Tissue Laboratory of Prof. Yves Poumay and Prof. Catherine Lambert (URPhyM, UNamur) previously set up an in vitro model of atopic dermatitis (AD). They showed that plasma membrane cholesterol depletion using methyl-beta-cyclodextrin (MβCD) in reconstructed human epidermis (RHE), followed by exposure to a mixture of IL-4, IL-13 and IL-25, mimics the hallmarks of AD lesions. More recently, they completed this previous work by studying the role played by each individual IL. IL-4 incubation after MβCD treatment induced the strongest morphological alterations and weakening of barrier function in this RHE model.
Involvement of S100A8/A9 in primary Sjögren's syndrome (pSS) Sjögren's syndrome is a chronic inflammatory autoimmune disorder, characterized by lymphocytic infiltration of exocrine glands, in particular lacrimal and salivary glands. S100A8 and S100A9 are two calcium-binding proteins, mainly expressed as a heterodimer by phagocytes. S100A8/A9 heterodimer is known to play central roles in inflammatory processes. In collaboration with the Laboratory of Bone and Metabolic Biochemistry of the ULB and the Department of Rheumatology of the Erasme Hospital, Prof. Charles Nicaise (URPhyM, UNamur) studied the role of S100A8/A9 in the pathogenesis of pSS. Their study shows that the expression of S100A8/A9 is upregulated in pSS patients and triggers the secretion of pro-inflammatory cytokines by PBMCs in vitro.